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Sucralose granular - granular, Pharmaceutical grade, Ph. Eur., JPE, NF, high purity , CAS No.56038-13-2

13 Citations
Item Number
S432919
Grouped product items
SKUSizeAvailabilityPrice Qty
S432919-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$156.90
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Basic Description

Synonyms4,1',6'-Trichloro-4,1',6'-trideoxy-galacto-sucrose | Biocoline | CCG-213995 | Sucrazit | CCRIS 8449 | Citric acid, trisodium salt | INS-955 | SUCRALOSE [II] | AKOS015962432 | alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chl
Specifications & Puritypharmaceutical grade, PharmPure™, Ph.Eur., JPE, granular
Biochemical and Physiological MechanismsA synthetic sweet tastant detectable by humans. Activates T1R2/T1R3 sweet taste receptors on enteroendocrine cells and elicits increased hormonal secretion of Glukagon-like peptide-1 and glucose-dependent insulinotrophic peptide.
Storage TempRoom temperature
Shipped InNormal
GradeJPE, Ph.Eur., pharmaceutical grade, PharmPure™
Product Description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production. As part of our EMPROVE ® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC ® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.


Application

Sucralose is a high-intensity sweetener which is non-cariogenic and suitable for diabetics and patients with an impaired glucose tolerance. In addition, it is readily soluble and masks both bitterness and medicinal off-notes with equal ease – making it exceptionally well-suited for pharmaceutical applications. Our Sucralose is available in micronized or granular form, both pharmaceutical grade, allowing you to choose depending on your individual needs. Due to its optimal dispersion behavior, sucralose powder is typically recommended for solid dose formulations, while the fast dissolution behavior of sucralose granular makes it very well-suited for liquid formulations.

Associated Targets(Human)

CA2 Tclin Carbonic anhydrase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R31 Tchem Taste receptor type 2 member 31 (86 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R10 Tchem Taste receptor type 2 member 10 (51 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R46 Tchem Taste receptor type 2 member 46 (155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
INCHI InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
InChi Key BAQAVOSOZGMPRM-QBMZZYIRSA-N
Canonical SMILES C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
Isomeric SMILES C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O
WGK Germany 3
RTECS LW5440140
PubChem CID 71485
Molecular Weight 397.63
Beilstein 3654410
Reaxy-Rn 3654410

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Specific Rotation[α]86.0° (C=1,H2O)
Melt Point(°C)130°C

Safety and Hazards(GHS)

WGK Germany 3
RTECS LW5440140
Reaxy-Rn 3654410
Merck Index 8880

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Lingling Tian, Jingyan Shi, Wei Li, Yuan Zhang, Xinghua Gao.  (2023)  Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation.  Advanced Healthcare Materials,    (6): (2302104).  [PMID:37751946] [10.1002/adhm.202302104]
2. He Yue, Chen Jianshe, Shi Weiyao, Shi Jingang, Ma Tian, Wang Xinmiao.  (2023)  Can nonvolatile tastants be smelled during food oral processing?.  CHEMICAL SENSES,  48    [PMID:37590987] [10.1093/chemse/bjad028]
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]
4. Xue Mei, Wenchang Wang, Qingyi Li, Minxian Wu, Liyin Bu, Zhidong Chen.  (2023)  A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.  ANALYST,  148  (10): (2335-2342).  [PMID:37186001] [10.1039/D3AN00368J]
5. Xuejiao Zhang, Jiaxin Gu, Congying Zhao, Yaozhong Hu, Bowei Zhang, Jin Wang, Huan Lv, Xuemeng Ji, Shuo Wang.  (2022)  Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (1): (171–183).  [PMID:34962394] [10.1021/acs.jafc.1c06788]
6. Xiaofeng Wei, Ying Chen, Shan He, Huiting Lian, Xuegong Cao, Bin Liu.  (2021)  L-histidine-regulated zeolitic imidazolate framework modified electrochemical interface for enantioselective determination of L-glutamate.  ELECTROCHIMICA ACTA,  400  (139464).  [PMID:] [10.1016/j.electacta.2021.139464]
7. Ferry Saputra, Yu-Heng Lai, Rey Arturo T. Fernandez, Allan Patrick G. Macabeo, Hong-Thih Lai, Jong-Chin Huang, Chung-Der Hsiao.  (2021)  Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae.  Biology-Basel,  10  (6): (548).  [PMID:34207293] [10.3390/biology10060548]
8. Pingping Cui, Qiuxiang Yin, Shihao Zhang, Xiaowei Cheng, Jiayu Dai, Zaixiang Zhang, Ling Zhou, Chuang Xie.  (2020)  The effect of solvents on crystal morphology of sucralose: Experiments and molecular dynamics simulation studies.  JOURNAL OF CRYSTAL GROWTH,  532  (125398).  [PMID:] [10.1016/j.jcrysgro.2019.125398]
9. Yong Li, Tingting Yang, Qing Yao, Songsong Li, En Fang, Yankun Li, Chao Liu, Weimin Li.  (2019)  Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.  NEUROGASTROENTEROLOGY AND MOTILITY,  31  (5): (e13556).  [PMID:30740845] [10.1111/nmo.13556]
10. Yin Xu, Ying Wu, Wei Zhang, Xiaohui Fan, Yan Wang, Hui Zhang.  (2018)  Performance of artificial sweetener sucralose mineralization via UV/O3 process: Kinetics, toxicity and intermediates.  CHEMICAL ENGINEERING JOURNAL,  353  (626).  [PMID:] [10.1016/j.cej.2018.07.090]
11. Hongmei Zhang, Shixin Sun, Yanqing Wang, Zhenghao Fei, Jian Cao.  (2018)  Binding mechanism of five typical sweeteners with bovine serum albumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  205  (40).  [PMID:30015031] [10.1016/j.saa.2018.07.013]
12. Hongmei Zhang, Shixin Sun, Yanqing Wang, Jian Cao.  (2017)  Interaction of sucralose with whey protein: Experimental and molecular modeling studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  187  (92).  [PMID:28666158] [10.1016/j.saa.2017.06.030]
13. Jiang Ting-Fu, Chong Lei, Yue Mei-E, Wang Yuan-Hong, Lv Zhi-Hua.  (2015)  Separation and Determination of Carbohydrates in Food Samples by Capillary Electrophoresis Using Dynamically Coating the Capillary with Indirect UV Detection.  Food Analytical Methods,  8  (10): (2588-2594).  [PMID:] [10.1007/s12161-015-0157-z]

References

1. Lingling Tian, Jingyan Shi, Wei Li, Yuan Zhang, Xinghua Gao.  (2023)  Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation.  Advanced Healthcare Materials,    (6): (2302104).  [PMID:37751946] [10.1002/adhm.202302104]
2. He Yue, Chen Jianshe, Shi Weiyao, Shi Jingang, Ma Tian, Wang Xinmiao.  (2023)  Can nonvolatile tastants be smelled during food oral processing?.  CHEMICAL SENSES,  48    [PMID:37590987] [10.1093/chemse/bjad028]
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]
4. Xue Mei, Wenchang Wang, Qingyi Li, Minxian Wu, Liyin Bu, Zhidong Chen.  (2023)  A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.  ANALYST,  148  (10): (2335-2342).  [PMID:37186001] [10.1039/D3AN00368J]
5. Xuejiao Zhang, Jiaxin Gu, Congying Zhao, Yaozhong Hu, Bowei Zhang, Jin Wang, Huan Lv, Xuemeng Ji, Shuo Wang.  (2022)  Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (1): (171–183).  [PMID:34962394] [10.1021/acs.jafc.1c06788]
6. Xiaofeng Wei, Ying Chen, Shan He, Huiting Lian, Xuegong Cao, Bin Liu.  (2021)  L-histidine-regulated zeolitic imidazolate framework modified electrochemical interface for enantioselective determination of L-glutamate.  ELECTROCHIMICA ACTA,  400  (139464).  [PMID:] [10.1016/j.electacta.2021.139464]
7. Ferry Saputra, Yu-Heng Lai, Rey Arturo T. Fernandez, Allan Patrick G. Macabeo, Hong-Thih Lai, Jong-Chin Huang, Chung-Der Hsiao.  (2021)  Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae.  Biology-Basel,  10  (6): (548).  [PMID:34207293] [10.3390/biology10060548]
8. Pingping Cui, Qiuxiang Yin, Shihao Zhang, Xiaowei Cheng, Jiayu Dai, Zaixiang Zhang, Ling Zhou, Chuang Xie.  (2020)  The effect of solvents on crystal morphology of sucralose: Experiments and molecular dynamics simulation studies.  JOURNAL OF CRYSTAL GROWTH,  532  (125398).  [PMID:] [10.1016/j.jcrysgro.2019.125398]
9. Yong Li, Tingting Yang, Qing Yao, Songsong Li, En Fang, Yankun Li, Chao Liu, Weimin Li.  (2019)  Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.  NEUROGASTROENTEROLOGY AND MOTILITY,  31  (5): (e13556).  [PMID:30740845] [10.1111/nmo.13556]
10. Yin Xu, Ying Wu, Wei Zhang, Xiaohui Fan, Yan Wang, Hui Zhang.  (2018)  Performance of artificial sweetener sucralose mineralization via UV/O3 process: Kinetics, toxicity and intermediates.  CHEMICAL ENGINEERING JOURNAL,  353  (626).  [PMID:] [10.1016/j.cej.2018.07.090]
11. Hongmei Zhang, Shixin Sun, Yanqing Wang, Zhenghao Fei, Jian Cao.  (2018)  Binding mechanism of five typical sweeteners with bovine serum albumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  205  (40).  [PMID:30015031] [10.1016/j.saa.2018.07.013]
12. Hongmei Zhang, Shixin Sun, Yanqing Wang, Jian Cao.  (2017)  Interaction of sucralose with whey protein: Experimental and molecular modeling studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  187  (92).  [PMID:28666158] [10.1016/j.saa.2017.06.030]
13. Jiang Ting-Fu, Chong Lei, Yue Mei-E, Wang Yuan-Hong, Lv Zhi-Hua.  (2015)  Separation and Determination of Carbohydrates in Food Samples by Capillary Electrophoresis Using Dynamically Coating the Capillary with Indirect UV Detection.  Food Analytical Methods,  8  (10): (2588-2594).  [PMID:] [10.1007/s12161-015-0157-z]

Solution Calculators

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