Sulfamethoxazole, one of the most studied inhibitors of Platelet Cox, is an acid excretory agent that reabsorbs Competitive inhibition acid in the proximal tubules of the kidney.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST, INHIBITOR
Mechanism of action
Antagonist of FPR1;Inhibitor of Urate anion exchanger 1
Note
Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Describtion:
Sulfinpyrazone is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).
Product Application：
cleaning products，cosmetics，food and beverages，forensics and toxicology，personal care，pharmaceutical (small molecule)，veterinary
Associated Targets(Human)
SLC22A12TclinSolute carrier family 22 member 12 (1 Activities)
1.Jingxuan Qiu, Xinzhu Zhao, Gang Liu, Chaoqun Zhang, Libo Wang, Yeming Wang, Shizhe Li, Lei Wang, Cen Yao, Liping Zhao, Peng Wang, Jia Zhang, Jing Lin, Rui Zhang, Yunchun Guo, Huiliang Wang. (2023) Solubility Behavior and Data Correlation of Sulfinpyrazone in Thirteen Pure Solvents from 283.15 to 323.15 K. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 68 (12):(3457–3466). [PMID:6336315][10.1021/acs.jced.3c00463]
2.Chen Sun, Mingyu Zhang, Yanhong Zhao, Jianxin Pang, Ying Peng, Jiang Zheng. (2020) An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1159 (122336). [PMID:32905987][10.1016/j.jchromb.2020.122336]
References
1.Jingxuan Qiu, Xinzhu Zhao, Gang Liu, Chaoqun Zhang, Libo Wang, Yeming Wang, Shizhe Li, Lei Wang, Cen Yao, Liping Zhao, Peng Wang, Jia Zhang, Jing Lin, Rui Zhang, Yunchun Guo, Huiliang Wang. (2023) Solubility Behavior and Data Correlation of Sulfinpyrazone in Thirteen Pure Solvents from 283.15 to 323.15 K. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 68 (12):(3457–3466). [PMID:6336315][10.1021/acs.jced.3c00463]
2.Chen Sun, Mingyu Zhang, Yanhong Zhao, Jianxin Pang, Ying Peng, Jiang Zheng. (2020) An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1159 (122336). [PMID:32905987][10.1016/j.jchromb.2020.122336]
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F2224204