Sulindac - ≥98%, high purity , Cyclooxygenase inhibitor, CAS No.38194-50-2, Cyclooxygenase inhibitor

Item Number

S125148

• Synonyms: sulindac|Clinoril|38194-50-2|Arthrocine|Sulindacum|Aflodac|Artribid|Mobilin|Sulindaco|Sulreuma|Sulindac sulfoxide|Algocetil|Citireuma|Clisundac|Imbaral|Reumofil|Sulinol|Sudac|(Z)-2-(5-Fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. Sulindac metabolizes to sulindac sulfide, a Cox (cyclooxygen
• Shipped In: Normal
• Grade: Moligand™
• Action Type: ANTAGONIST, INHIBITOR
• Mechanism of action: Cyclooxygenase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class.
Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-