Grouped product items

SKU

Size

Availability

Price

Qty

S412603-25mg

25mg

Available within 8-12 weeks(?)

$3,283.90

Basic Description

Synonyms	Sulopenem \| 120788-07-0 \| CP-70429 \| CP-70,429 \| XX514BJ1XW \| CP 70429 \| SULOPENEM [INN] \| Sulopenem (USAN/INN) \| SULOPENEM [USAN] \| SCHEMBL2256409 \| CHEMBL1908305 \| Sulopenem, >=98% (HPLC) \| GTPL10862 \| DTXSID20869656 \| (5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(3S)-tetrahydro-3-th
Specifications & Purity	Moligand™
Biochemical and Physiological Mechanisms	Sulopenem (CP-70429) is an orally active, potent inhibitor of beta-lactamase. Sulopenem is a parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Bacterial penicillin-binding protein inhibitor
Product Description	Information Sulopenem (CP-70429) is an orally active, potent inhibitor of beta-lactamase. Sulopenem is a parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria.

Associated Targets(non-human)

Streptococcus pneumoniae (31063 Activities)

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Eggerthella lenta (139 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Parabacteroides distasonis (282 Activities)

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Porphyromonas gingivalis (651 Activities)

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Fusobacterium mortiferum (179 Activities)

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Fusobacterium varium (184 Activities)

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Fusobacterium necrophorum (183 Activities)

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Peptoniphilus asaccharolyticus (368 Activities)

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Peptostreptococcus anaerobius (347 Activities)

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Bacteroides uniformis (255 Activities)

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Phocaeicola vulgatus (440 Activities)

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Hoylesella loescheii (67 Activities)

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Fusobacterium nucleatum (386 Activities)

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Finegoldia magna (323 Activities)

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Paraclostridium bifermentans (60 Activities)

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Clostridium butyricum (54 Activities)

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Clostridioides difficile (2968 Activities)

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Clostridium perfringens (1165 Activities)

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Clostridium cadaveris (57 Activities)

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Thomasclavelia ramosa (78 Activities)

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Paeniclostridium sordellii (66 Activities)

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Clostridium tertium (174 Activities)

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Cutibacterium acnes (887 Activities)

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Bacteroides ovatus (282 Activities)

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Prevotella bivia (313 Activities)

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Prevotella buccae (219 Activities)

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Prevotella disiens (96 Activities)

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Prevotella melaninogenica (262 Activities)

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Hoylesella oralis (105 Activities)

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Anaerococcus prevotii (218 Activities)

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Parvimonas micra (315 Activities)

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Prevotella intermedia (369 Activities)

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Anaerococcus tetradius (97 Activities)

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Bacteroides stercoris (113 Activities)

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Enterocloster clostridioformis (80 Activities)

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[Clostridium] innocuum (129 Activities)

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Porphyromonas asaccharolytica (102 Activities)

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Prevotella corporis (100 Activities)

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Prevotella denticola (82 Activities)

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Prevotella nigrescens (68 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(1R,3S)-1-oxothiolan-3-yl]sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
INCHI	InChI=1S/C12H15NO5S3/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6/h5-7,10,14H,2-4H2,1H3,(H,16,17)/t5-,6+,7+,10-,21-/m1/s1
InChi Key	FLSUCZWOEMTFAQ-PRBGKLEPSA-N
Canonical SMILES	CC(C1C2N(C1=O)C(=C(S2)SC3CCS(=O)C3)C(=O)O)O
Isomeric SMILES	C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(S2)S[C@H]3CC[S@@](=O)C3)C(=O)O)O
PubChem CID	9950244
Molecular Weight	349.45

Database links

PubChem CID	9950244
CAS Registry No.	120788-07-0
ChEMBL Ligand	CHEMBL1908305
DrugBank Ligand	DB15284
Antibiotic DB	391, 1869

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

RIDADR	NONHforallmodesoftransport

References

1. Okamoto K, Gotoh N, Nishino T. (2001) Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay.. Antimicrob Agents Chemother, 45 (7): (1964-71). [PMID:11408209]
2. Minamimura M, Taniyama Y, Inoue E, Mitsuhashi S. (1993) In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic.. Antimicrob Agents Chemother, 37 (7): (1547-51). [PMID:8363389]
3. Kosowska-Shick K, Ednie LM, McGhee P, Appelbaum PC. (2009) Comparative antipneumococcal activities of sulopenem and other drugs.. Antimicrob Agents Chemother, 53 (6): (2239-47). [PMID:19307366]

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Sulopenem , Bacterial penicillin-binding protein inhibitor, CAS No.120788-07-0, Bacterial penicillin-binding protein inhibitor

Basic Description

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator