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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
S336434-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $19.90 | |
S336434-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $75.90 | |
S336434-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $129.90 | |
S336434-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
S336434-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $479.90 | |
S336434-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $479.90 |
a benzenesulfonamide derivative
Synonyms | 4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide | 4-(Tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-benzenesulfonamide | 4-sulfamoyl-phenyl-[1,2]thiazinane-1 | 1-dioxide, Sultiame |
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Specifications & Purity | ≥96% |
Biochemical and Physiological Mechanisms | Sulthiame is a carbonic anhydrase (CA) inhibitor (hCA Ki in nM = 374/I, 7/II, 95/IV, 81/VA, 91/VB, 134/VI, 6/VII, 43/IX, 56/XII; Ki = 630 mM/hCA III, 1.45 μM/mCA XIII, 1.54 μM/hCA XIV) with anticonvulsant efficacy in vivo. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Carbonic anhydrase inhibitor |
Product Description | Product Application: Sulthiame is a benzenesulfonamide derivative. Sulthiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy. |
pKa | pKₐ: 9.9 (Predicted) |
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Ki Data | CA II: Ki= 9 nM (human); CA IX: Ki= 43 nM (human); &alpha carbonic anhydrase: Ki= 45.2 nM (Stylophora pistillata); CA VI: Ki= 134 nM (human); CA I: Ki= 374 nM (human) |
ALogP | 0.1 |
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IUPAC Name | 4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide |
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INCHI | InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16) |
InChi Key | HMHVCUVYZFYAJI-UHFFFAOYSA-N |
Canonical SMILES | C1CCS(=O)(=O)N(C1)C2=CC=C(C=C2)S(=O)(=O)N |
Isomeric SMILES | C1CCS(=O)(=O)N(C1)C2=CC=C(C=C2)S(=O)(=O)N |
PubChem CID | 5356 |
Molecular Weight | 290.36 |
Beilstein | 1222219 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
10 results found
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2410377 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410378 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410379 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410380 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410381 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410382 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410383 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410384 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410385 | Certificate of Analysis | Jun 19, 2024 | S336434 |
I2410386 | Certificate of Analysis | Jun 19, 2024 | S336434 |
Solubility | Soluble in methanol, and DMSO. |
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Refractive Index | n20D1.61 (Predicted) |
Boil Point(°C) | ~520.2° C at 760 mmHg (Predicted) |
Melt Point(°C) | 177-179° C |