Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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S614267-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $570.90 | |
S614267-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,000.90 |
Synonyms | KBioGR_001774 | 3-14-00-02267 (Beilstein Handbook Reference) | 8,8'-(UREYLENEBIS(M-PHENYLENECARBONYLIMINO(4-METHYL-M-PHENYLENE)CARBONYLIMINO))DI-1,3,5-NAPHTHALENETRISULFONIC ACID | NSC34936 | NSC-34936 | Naganol | DB04786 | DivK1c_006758 | Farma 939 | L00 |
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Specifications & Purity | Moligand™ |
Grade | Moligand™ |
Action Type | ACTIVATOR, ANTAGONIST |
Mechanism of action | Antagonist of P2X1;Antagonist of P2X2;Antagonist of P2X3;Antagonist of P2X5;Antagonist of P2Y 11 receptor;Antagonist of P2Y 13 receptor;Antagonist of P2Y 1 receptor;Antagonist of P2Y 2 receptor;Antagonist of P2Y 6 receptor;Activator of RyR1;Activator of R |
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IUPAC Name | 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid |
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INCHI | InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) |
InChi Key | FIAFUQMPZJWCLV-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C |
Isomeric SMILES | CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C |
Alternate CAS | 145-63-1,129-46-4,129-46-4 (hexa-hydrochloride salt) |
PubChem CID | 5361 |
NSC Number | 34936 |
MeSH Entry Terms | Germanin;Hexasodium Salt Suramin;Monosodium Salt Suramin;Moranil;Naganin;Naganol;Naphuride;Salt Suramin, Hexasodium;Salt Suramin, Monosodium;Sodium, Suramin;Suramin;Suramin Sodium;Suramin, Hexasodium Salt;Suramin, Monosodium Salt |
PubChem CID | 5361 |
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DrugBank Ligand | DB04786 |
CAS Registry No. | 145-63-1 |
ChEBI | CHEBI:45906 |
Wikipedia | Suramin |
ChEMBL Ligand | CHEMBL265502 |
BindingDB Ligand | 50336799 |
RCSB PDB Ligand | SVR |
DrugCentral Ligand | 2966 |
GPCRdb Ligand | suramin |
Enter Lot Number to search for COA:
1. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Séguéla P, Voigt M, Humphrey PP. (2001) International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.. Pharmacol Rev, 53 (1): (107-18). [PMID:11171941] [10.1021/op500134e] |
2. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA et al.. (2006) International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.. Pharmacol Rev, 58 (3): (281-341). [PMID:16968944] [10.1021/op500134e] |
3. Wolner I, Kassack MU, Ullmann H, Karel A, Hohenegger M. (2005) Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676.. Br J Pharmacol, 146 (4): (525-33). [PMID:16056233] [10.1021/op500134e] |
4. Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL et al.. (2013) Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.. PLoS ONE, 8 (3): (e57380). [PMID:23516405] [10.1021/op500134e] |
5. Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell SB, Naviaux RK. (2014) Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.. Transl Psychiatry, 4 (13): (e400). [PMID:24937094] [10.1021/op500134e] |
6. Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell SB, Naviaux RK. (2015) Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.. Mol Autism, 6 (13): (1). [PMID:25705365] [10.1021/op500134e] |