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suramin , CAS No.145-63-1, Antagonist of P2X1;Antagonist of P2X2;Antagonist of P2X3;Antagonist of P2X5;Antagonist of P2Y 11 receptor;Antagonist of P2Y 13 receptor;Antagonist of P2Y 1 receptor;Antagonist of P2Y 2 receptor;Antagonist of P2Y 6 receptor;Activator of RyR1;Activator of R

  • Moligand™
Item Number
S614267
Grouped product items
SKUSizeAvailabilityPrice Qty
S614267-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$570.90
S614267-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
P2X1 Antagonist P2X2 Antagonist P2X3 Antagonist P2X5 Antagonist P2Y1 receptor Antagonist P2Y11 receptor Antagonist P2Y13 receptor Antagonist P2Y2 receptor Antagonist P2Y6 receptor Antagonist RyR1 Activator RyR2 Activator

Basic Description

Synonymssuramin|Naganol|Suramine|Fourneau|Farma|145-63-1|Germanin|Belganyl|Naphuride|Sodium suramin|Naganin|Farma 939|Antrypol|Moranyl|Metaret|Naganine|Suramine sodium|Bayer 205|NSC-34936|FARMA-939|m,m'-Ureylen-bis-(8-(m-(benzamido)-p-toluamido)naphthalin-1,3,5-t
Specifications & PurityMoligand™
GradeMoligand™
Action TypeACTIVATOR, ANTAGONIST
Mechanism of actionAntagonist of P2X1;Antagonist of P2X2;Antagonist of P2X3;Antagonist of P2X5;Antagonist of P2Y 11 receptor;Antagonist of P2Y 13 receptor;Antagonist of P2Y 1 receptor;Antagonist of P2Y 2 receptor;Antagonist of P2Y 6 receptor;Activator of RyR1;Activator of R

Names and Identifiers

IUPAC Name 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
INCHI InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
InChi Key FIAFUQMPZJWCLV-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
Isomeric SMILES CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
Alternate CAS 145-63-1,129-46-4,129-46-4 (hexa-hydrochloride salt)
PubChem CID 5361
NSC Number 34936
MeSH Entry Terms Germanin;Hexasodium Salt Suramin;Monosodium Salt Suramin;Moranil;Naganin;Naganol;Naphuride;Salt Suramin, Hexasodium;Salt Suramin, Monosodium;Sodium, Suramin;Suramin;Suramin Sodium;Suramin, Hexasodium Salt;Suramin, Monosodium Salt

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Séguéla P, Voigt M, Humphrey PP.  (2001)  International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits..  Pharmacol Rev,  53  (1): (107-18).  [PMID:11171941]
2. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA et al..  (2006)  International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy..  Pharmacol Rev,  58  (3): (281-341).  [PMID:16968944]
3. Wolner I, Kassack MU, Ullmann H, Karel A, Hohenegger M.  (2005)  Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676..  Br J Pharmacol,  146  (4): (525-33).  [PMID:16056233]
4. Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL et al..  (2013)  Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model..  PLoS ONE,  8  (3): (e57380).  [PMID:23516405]
5. Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell SB, Naviaux RK.  (2014)  Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy..  Transl Psychiatry,  4  (3): (e400).  [PMID:24937094]
6. Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell SB, Naviaux RK.  (2015)  Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model..  Mol Autism,  6  (3): (1).  [PMID:25705365]

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