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Surfen dihydrochloride - ≥98%(HPLC), high purity , CAS No.5424-37-3

≥98%(HPLC)

CAS#: 5424-37-3
Formula: C₂₁H₂₂Cl₂N₆O
Molecular Weight: 445.35
PubChem CID: 79472

Item Number

S286940

Grouped product items
SKU	Size	Availability	Price
S286940-1mg	1mg	In stock	$24.90
S286940-5mg	5mg	In stock	$102.90
S286940-10mg	10mg	In stock	$162.90

Heparin sulfate antagonist

Basic Description

Synonyms	AKOS030527176 \| EINECS 226-566-0 \| Tox21_110013 \| 1,3-Bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride \| DTXSID1045083 \| NSC 12155 \| MFCD00051734 \| Surfen dihydrochloride \| Aminoquincarbamide dihydrochloride \| Luminor Yellow Green 490RT \| P2YT71SUIU \|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Heparan sulfate antagonist. Inhibits heparan sulfate-mediated cell attachmentin vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product Describtion: Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection.

Associated Targets(Human)

KMT2A Tchem Histone-lysine N-methyltransferase 2A (0 Activities)

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1,3-bis(4-amino-2-methylquinolin-6-yl)urea;dihydrochloride
INCHI	InChI=1S/C21H20N6O.2ClH/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);2*1H
InChi Key	GKQYGRWQCWWSHN-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N)N.Cl.Cl
Isomeric SMILES	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N)N.Cl.Cl
PubChem CID	79472
Molecular Weight	445.35

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
G23201112	Certificate of Analysis	Jun 27, 2023	S286940
G23201113	Certificate of Analysis	Jun 27, 2023	S286940
G23201116	Certificate of Analysis	Jun 27, 2023	S286940
G23201118	Certificate of Analysis	Jun 27, 2023	S286940
G23201120	Certificate of Analysis	Jun 27, 2023	S286940
G23201125	Certificate of Analysis	Jun 27, 2023	S286940

Solubility

Solvent:water, Max Conc. mg/mL: 8.91, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 8.91, Max Conc. mM: 20

Sensitivity

light sensitive；Moisture sensitive.

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Surfen dihydrochloride - ≥98%(HPLC), high purity , CAS No.5424-37-3

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Solution Calculators

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Dilution Calculator

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