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SX-517 , CAS No.S614275, Antagonist of CXCR2
Basic Description
| Synonyms | SX-517 | 1240494-13-6 | 36UH926WTQ | GTPL8501 | CHEMBL3342269 | SCHEMBL13197143 | BDBM150811 | SX517 | AKOS040749589 | HY-12927 | CS-0012790 | US8981106, 1 (SX-517) | Q27088898 | (2-(((5-((4-Fluorophenyl)carbamoyl)pyridin-2-yl)thio)methyl)phenyl)boronic acid | [2-[[5-[(4-fluoropheny |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | ANTAGONIST |
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| Mechanism of action | Antagonist of CXCR2 |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | [2-[[5-[(4-fluorophenyl)carbamoyl]pyridin-2-yl]sulfanylmethyl]phenyl]boronic acid |
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| INCHI | InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24) |
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| InChi Key | VZRIHFZJVIOJBE-UHFFFAOYSA-N |
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| Canonical SMILES | Fc1ccc(cc1)NC(=O)c1ccc(nc1)SCc1ccccc1B(O)O |
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| Isomeric SMILES | B(C1=CC=CC=C1CSC2=NC=C(C=C2)C(=O)NC3=CC=C(C=C3)F)(O)O |
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| PubChem CID | 46897162 |
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References
| 1. Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Fan GH, Zebala JA. (2014) Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.. J Med Chem, 57 (20): (8378-97). [PMID:25254640] |
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