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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S274810-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
S274810-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $162.90 | |
S274810-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $424.90 | |
S274810-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $849.90 | |
S274810-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,529.90 |
Potent, selective inhibitor of B cell signaling and function
Synonyms | 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONICACIDAMIDE | 3-[(1-methyl-1H-indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | N-Boc-4-phenylnipecoticacid | DTXSID30648015 | (Z)-3-((1-methyl-1H-indol-3-yl)methylene)-2-ox |
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Specifications & Purity | Moligand™, ≥98%, mixture of isomers |
Biochemical and Physiological Mechanisms | Potent, selective inhibitor of B cell signaling and function. (IC 50 = 14 nM) Cell permeable. Active in vitro and in vivo. |
Storage Temp | Protected from light,Store at -20°C,Argon charged,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of spleen associated tyrosine kinase |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 3-[(1-methylindol-3-yl)methylidene]-2-oxo-1H-indole-5-sulfonamide |
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INCHI | InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24) |
InChi Key | MLKHXLFEYOOYEY-UHFFFAOYSA-N |
Canonical SMILES | CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O |
Isomeric SMILES | CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O |
PubChem CID | 24906266 |
Molecular Weight | 353.39 |
PubChem CID | 6419747 |
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ChEMBL Ligand | CHEMBL104279 |
CAS Registry No. | 622387-85-3 |
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Solubility | Soluble in DMSO to 10 mM |
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Sensitivity | light sensitive |
1. Lai JY, Cox PJ, Patel R, Sadiq S, Aldous DJ, Thurairatnam S, Smith K, Wheeler D, Jagpal S, Parveen S et al.. (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk).. Bioorg Med Chem Lett, 13 (18): (3111-4). [PMID:12941345] |