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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S274810-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
S274810-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $162.90 | |
S274810-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $424.90 | |
S274810-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $849.90 | |
S274810-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,529.90 |
Potent, selective inhibitor of B cell signaling and function
Synonyms | 622387-85-3|3-[(1-methyl-3-indolyl)methylidene]-2-oxo-1H-indole-5-sulfonamide|3-[(1-methylindol-3-yl)methylidene]-2-oxo-1H-indole-5-sulfonamide|OXSI 2|N-Boc-4-phenylnipecoticacid|DTXSID30648015|Q27164252|(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-2-oxoindo |
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Specifications & Purity | ≥98.0%(mixture of isomers) |
Storage Temp | Protected from light,Store at -20°C,Argon charged,Desiccated |
Shipped In | Dry ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of spleen associated tyrosine kinase |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 3-[(1-methylindol-3-yl)methylidene]-2-oxo-1H-indole-5-sulfonamide |
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INCHI | InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24) |
InChi Key | MLKHXLFEYOOYEY-UHFFFAOYSA-N |
Canonical SMILES | CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O |
Isomeric SMILES | CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O |
PubChem CID | 24906266 |
Molecular Weight | 353.39 |
PubChem CID | 6419747 |
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ChEMBL Ligand | CHEMBL104279 |
CAS Registry No. | 622387-85-3 |
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Solubility | Soluble in DMSO to 10 mM |
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Sensitivity | light sensitive |
1. Lai JY, Cox PJ, Patel R, Sadiq S, Aldous DJ, Thurairatnam S, Smith K, Wheeler D, Jagpal S, Parveen S et al.. (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk).. Bioorg Med Chem Lett, 13 (18): (3111-4). [PMID:12941345] |