Syk Inhibitor(Isomer mixture) - ≥98.0%(mixture of isomers), high purity , CAS No.622387-85-3, Inhibitor of spleen associated tyrosine kinase

Item Number
S274810
Grouped product items
SKUSizeAvailabilityPrice Qty
S274810-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
S274810-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$162.90
S274810-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$424.90
S274810-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$849.90
S274810-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,529.90

Potent, selective inhibitor of B cell signaling and function

Basic Description

Synonyms3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONICACIDAMIDE | 3-[(1-methyl-1H-indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | N-Boc-4-phenylnipecoticacid | DTXSID30648015 | (Z)-3-((1-methyl-1H-indol-3-yl)methylene)-2-ox
Specifications & PurityMoligand™, ≥98%, mixture of isomers
Biochemical and Physiological MechanismsPotent, selective inhibitor of B cell signaling and function. (IC 50 = 14 nM) Cell permeable. Active in vitro and in vivo.
Storage TempProtected from light,Store at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of spleen associated tyrosine kinase
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

FCER2 Tchem Low affinity immunoglobulin epsilon Fc receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SYK Tclin Tyrosine-protein kinase SYK (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK2 Tclin BDNF/NT-3 growth factors receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK1 Tclin High affinity nerve growth factor receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK3 Tclin NT-3 growth factor receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-[(1-methylindol-3-yl)methylidene]-2-oxo-1H-indole-5-sulfonamide
INCHI InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)
InChi Key MLKHXLFEYOOYEY-UHFFFAOYSA-N
Canonical SMILES CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O
Isomeric SMILES CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O
PubChem CID 24906266
Molecular Weight 353.39

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 10 mM
Sensitivitylight sensitive

Related Documents

References

1. Lai JY, Cox PJ, Patel R, Sadiq S, Aldous DJ, Thurairatnam S, Smith K, Wheeler D, Jagpal S, Parveen S et al..  (2003)  Potent small molecule inhibitors of spleen tyrosine kinase (Syk)..  Bioorg Med Chem Lett,  13  (18): (3111-4).  [PMID:12941345] [10.1021/op500134e]

Solution Calculators