Syk Inhibitor IV, BAY 61-3606 HCl - ≥97%, high purity , CAS No.732983-37-8, Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of spleen associated tyrosine kinase
Syk Inhibitor IV, BAY 61-3606 HCl - ≥97%, high purity , CAS No.732983-37-8, Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of spleen associated tyrosine kinase
BAY 61-3606|732983-37-8|BAY-61-3606 free base|2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide|Syk inhibitor IV|BAY61-3606|BAY 61-3606 free base|61G8S0H9KX|CHEMBL1190711|BAY-613606|3-Pyridinecarboxamide, 2-((7-(3,4-dime
Specifications & Purity
≥97%
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of spleen associated tyrosine kinase
Product Description
BAY 61-3606 (Syk inhibitor IV) is an active, ATP-competitive reversible selective Syk inhibitor. It acts on breast cancer cells and promotes TRAIL-induced apoptosis by down-regulating Mcl-1. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells, as well as Syk phosphorylation in K-rn cell lysates
Product Properties
Ki Data
Syk tyrosine kinase activity: Ki= 7.5 nM
Associated Targets
CDC7Tchem Cell division cycle 7-related protein kinase 0 Activities
1.Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, Ishimori M, Nagai H, Li YF, Yura T et al.. (2003) The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.. J Pharmacol Exp Ther, 306 (3):(1174-81). [PMID:12766258]
2.Ho CM, Donovan-Banfield IZ, Tan L, Zhang T, Gray NS, Strang BL. (2016) Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells.. PLoS ONE, 11 (3):(e0150339). [PMID:26930276]
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