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TKL:Tyrosine kinase-like
SZM594 , CAS No.S614280, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of receptor interacting serine/threonine kinase 1;Inhibitor of receptor interacting serine/threonine kinase 3

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SZM594 , CAS No.S614280, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of receptor interacting serine/threonine kinase 1;Inhibitor of receptor interacting serine/threonine kinase 3

Moligand™

PubChem CID: 138393290

Item Number

S614280

Grouped product items
SKU	Size	Availability	Price	Qty
S614280-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
S614280-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

B-Raf proto-oncogene，serine/threonine kinase Inhibitor receptor interacting serine/threonine kinase 1 Inhibitor receptor interacting serine/threonine kinase 3 Inhibitor

Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of receptor interacting serine/threonine kinase 1;Inhibitor of receptor interacting serine/threonine kinase 3

Associated Targets

RIPK3 Tchem Receptor-interacting serine/threonine-protein kinase 3 0 Activities

Discover Target: RIPK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 0 Activities

Discover Target: RIPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRAF Tclin Serine/threonine-protein kinase B-raf 0 Activities

Discover Target: BRAF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[6-(4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
INCHI	InChI=1S/C26H19F4N3O3S/c27-19-8-6-17(12-21(19)31-23(34)11-14-2-1-3-16(10-14)26(28,29)30)36-18-7-9-20-22(13-18)37-25(32-20)33-24(35)15-4-5-15/h1-3,6-10,12-13,15H,4-5,11H2,(H,31,34)(H,32,33,35)
InChi Key	SDSQERWTMKMZLA-UHFFFAOYSA-N
Canonical SMILES	O=C(Nc1cc(ccc1F)Oc1ccc2c(c1)sc(n2)NC(=O)C1CC1)Cc1cccc(c1)C(F)(F)F
Isomeric SMILES	C1CC1C(=O)NC2=NC3=C(S2)C=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F
PubChem CID	138393290

Database links

PubChem CID	138393290

Certificates

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References

1. Chen X, Zhuang C, Ren Y, Zhang H, Qin X, Hu L, Fu J, Miao Z, Chai Y, Liu ZG et al.. (2019) Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3.. Br J Pharmacol, 176 (12): (2095-2108). [PMID:30825190]

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