T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta ( PI4KB ) inhibitor with an IC 50 of 60 nM.
In Vitro
T-00127_HEV1 shows more potent anti-poliovirus (PV) activity (EC 50 of 0.77 μM) than other candidate compounds (EC 50 of 1.7 to 4.7 μM). GW5074 and T-00127_HEV1 almost completely inhibit PI4KB kinase activity at 10 μM (3% and 5% of residual activity, respectively), in contrast to AN-12-H5 (108% of activity [no inhibition]). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
