T 3364366 - ≥98%(HPLC), high purity , CAS No.1356354-09-0

Item Number

T286634

Grouped product items
SKU	Size	Availability	Price
T286634-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$109.90
T286634-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$177.90
T286634-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$400.90
T286634-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$720.90
T286634-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,297.90

Potent and reversible fatty acid desaturase 1 inhibitor

Basic Description

Synonyms	N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and reversible fatty acid desaturase 1 (FADS1; Δ5desaturase) inhibitor (IC50values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6desaturase). Inhibits arachidoni
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product description： T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay.

Associated Targets(non-human)

Scd1 Acyl-CoA desaturase 1 (506 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fads2 Fatty acid desaturase 2 (2 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fads1 Fatty acid desaturase 1 (2 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[2-[4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]sulfanylethyl]acetamide
INCHI	InChI=1S/C18H16F3N3O3S2/c1-11(25)22-6-7-29-17-23-15-9-28-8-14(15)16(26)24(17)12-2-4-13(5-3-12)27-10-18(19,20)21/h2-5,8-9H,6-7,10H2,1H3,(H,22,25)
InChi Key	BVRXQXNVDLUWMV-UHFFFAOYSA-N
Canonical SMILES	CC(=O)NCCSC1=NC2=CSC=C2C(=O)N1C3=CC=C(C=C3)OCC(F)(F)F
Isomeric SMILES	CC(=O)NCCSC1=NC2=CSC=C2C(=O)N1C3=CC=C(C=C3)OCC(F)(F)F
PubChem CID	86685411
Molecular Weight	443.46

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
C2320761	Certificate of Analysis	Dec 30, 2022	T286634
C2320762	Certificate of Analysis	Dec 30, 2022	T286634
C2320763	Certificate of Analysis	Dec 30, 2022	T286634
C2320764	Certificate of Analysis	Dec 30, 2022	T286634
C2320765	Certificate of Analysis	Dec 30, 2022	T286634

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Basic Description