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T 5601640 - 10mM in DMSO, high purity , CAS No.924473-59-6
Selective LIMK2 inhibitor; antitumor
Basic Description Synonyms T56-LIMKi;3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Selective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide INCHI InChI=1S/C19H14F3N3O3/c1-11-8-16(28-25-11)18(27)24-14-6-2-4-12(9-14)17(26)23-15-7-3-5-13(10-15)19(20,21)22/h2-10H,1H3,(H,23,26)(H,24,27) InChi Key XVOKFRPKSAWELK-UHFFFAOYSA-N Canonical SMILES CC1=NOC(=C1)C(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F Isomeric SMILES CC1=NOC(=C1)C(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F PubChem CID 9438169 UN Number 2811 Packing Group III Molecular Weight 389.33
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
H413: May cause long lasting harmful effects to aquatic life
Precautionary Statements P273: Avoid release to the environment.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P301+P310+P330: IF SWALLOWED: Rinse mouth.Immediately call a POISON CENTER/doctor/.
Class 6.1 RIDADR UN28116.1/PGIII
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