Basic Description

Synonyms	D-threonine\|632-20-2\|H-D-Thr-OH\|(2R,3S)-2-amino-3-hydroxybutanoic acid\|DL-Threonine\|(R)-Threonine\|Threonine, D-\|D-(+)-Threonine\|D-Threonin\|Allo-DL-threonine\|D-2-Amino-3-hydroxybutyric acid\|SG6FYY47DD\|CHEBI:16398\|80-68-2\|D-thr\|DTH\|6028-28-0\|MFCD00064269\|14
Specifications & Purity	≥99%
Shipped In	Normal
Product Description	A steroisomer of the proteinogenic amino acid L-threonine. product description： D-Threonine is sweet and toxic in nature.It acts as an inhibitor of L-threonine dehydratase. application： D-Threonine has been used as a constituent of standard mix in Ultra-high performance liquid chromatography (UHPLC) system for quantification of amino acid racemization.

Associated Targets

SLC1A5 Tchem Neutral amino acid transporter B(0) 0 Activities

Discover Target: SLC1A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488184324
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488184324
IUPAC Name	(2R,3S)-2-amino-3-hydroxybutanoic acid
INCHI	InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m0/s1
InChi Key	AYFVYJQAPQTCCC-STHAYSLISA-N
Canonical SMILES	C[C@H](O)[C@@H](N)C(O)=O
Isomeric SMILES	C[C@@H]([C@H](C(=O)O)N)O
WGK Germany	1
RTECS	XO8580000
PubChem CID	69435
Molecular Weight	119.12
Beilstein	1721643
Reaxy-Rn	1721643

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
G2419399	Certificate of Analysis	May 11, 2024	T100459
G2419403	Certificate of Analysis	May 11, 2024	T100459
G2419405	Certificate of Analysis	May 11, 2024	T100459
G2419406	Certificate of Analysis	May 11, 2024	T100459
B23171143	Certificate of Analysis	Feb 04, 2023	T100459
B23171185	Certificate of Analysis	Feb 04, 2023	T100459
B23171189	Certificate of Analysis	Feb 04, 2023	T100459
B23171206	Certificate of Analysis	Feb 04, 2023	T100459
B23171210	Certificate of Analysis	Feb 04, 2023	T100459
B2317939	Certificate of Analysis	Feb 04, 2023	T100459
B2318124	Certificate of Analysis	Feb 04, 2023	T100459
C2208112	Certificate of Analysis	Jul 22, 2021	T100459

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Chemical and Physical Properties

Solubility	Soluble in water (50 mg/ml).
Specific Rotation[α]	28 ° (C=3, H2O)
Melt Point(°C)	274°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	1
RTECS	XO8580000
Reaxy-Rn	1721643
Merck Index	9380

FAQs and Articles

FAQ

Editing sugar chains on therapeutic proteins with glycosidase

Categories: Technical articles

Tags:

Glycosylation aspartic acid Glycosidase protease dextran

References

1. J Q Liu,M Odani,T Yasuoka,T Dairi,N Itoh,M Kataoka,S Shimizu,H Yamada. (2000-08-22) Gene cloning and overproduction of low-specificity D-threonine aldolase from Alcaligenes xylosoxidans and its application for production of a key intermediate for parkinsonism drug.. Applied microbiology and biotechnology, 54 ((1)): (44-51). [PMID:10952004]
2. Kateryna Fesko,Lars Giger,Donald Hilvert. (2008-09-02) Synthesis of beta-hydroxy-alpha-amino acids with a reengineered alanine racemase.. Bioorganic & medicinal chemistry letters, 18 ((22)): (5987-5990). [PMID:18760921]
3. Yong Yang,Ling Fu,Jinlong Zhang,Linghan Hu,Minjuan Xu,Jun Xu. (2014-06-12) Characterization of the xiamenmycin biosynthesis gene cluster in Streptomyces xiamenensis 318.. PloS one, 9 ((6)): (e99537-e99537). [PMID:24919072]

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SKU	Size	Availability	Price
T100459-5g	5g	In stock	$21.90
T100459-25g	25g	In stock	$81.90
T100459-100g	100g	In stock	$243.90
T100459-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$729.90

H-D-Thr-OH - 99%, high purity , CAS No.632-20-2