Basic Description

Synonyms	(+/-)-alpha-Tocopherol \| (2R,8'R)-.alpha.-Tocopherol \| 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol \| DTXSID8021355 \| Spectrum5_000381 \| NSC82623 \| (.+/-.)-.alpha.-Tocopherol \| (2S, 4'S, 8'R)-alpha-Tocopherol \| Antisterility vi
Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	Tocopherols (vitamin E) comprise of a series (α, β, γ and δ) of chiral compounds that differ by the methylation degree of the phenol moiety of the chromanol ring. They function as lipid soluble antioxidants and protect cell membranes from oxidative damage
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	DL-α-Tocopherol is a physiological membrane-bound antioxidant that protects cell membrane lipids from oxidative damage by free radicals. An antioxidant that protects cell membrane lipids from oxidative damage

Associated Targets(Human)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau (0 Activities)

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PSEN1 Tchem Presenilin-1 (0 Activities)

Discover Target: PSEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PSEN1 Tchem Presenilin 1 (302 Activities)

Discover Target: PSEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Brain (1 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488179662
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179662
IUPAC Name	2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol
INCHI	InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
InChi Key	GVJHHUAWPYXKBD-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
Isomeric SMILES	CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
WGK Germany	1
RTECS	GA8746000
PubChem CID	2116
Molecular Weight	430.71
Beilstein	94012
Reaxy-Rn	1296133

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot Number	Certificate Type	Date	Item
B23111076	Certificate of Analysis	Nov 08, 2024	T105540
B23111075	Certificate of Analysis	Nov 08, 2024	T105540
B23111057	Certificate of Analysis	Nov 04, 2024	T105540
B23111088	Certificate of Analysis	Nov 04, 2024	T105540
B23111104	Certificate of Analysis	Nov 04, 2024	T105540
J2429116	Certificate of Analysis	Nov 04, 2024	T105540
L2115670	Certificate of Analysis	Sep 19, 2023	T105540
L2115669	Certificate of Analysis	Sep 19, 2023	T105540
L2115667	Certificate of Analysis	Sep 19, 2023	T105540
D2112026	Certificate of Analysis	Jan 13, 2023	T105540
D2112023	Certificate of Analysis	Jan 13, 2023	T105540
E2421063	Certificate of Analysis	Oct 31, 2022	T105540
E2429040	Certificate of Analysis	Oct 31, 2022	T105540
H2304166	Certificate of Analysis	Oct 31, 2022	T105540
B23111099	Certificate of Analysis	Oct 31, 2022	T105540
B23111062	Certificate of Analysis	Oct 31, 2022	T105540
B23111046	Certificate of Analysis	Oct 31, 2022	T105540
H2230037	Certificate of Analysis	Sep 05, 2022	T105540
E2322625	Certificate of Analysis	Nov 18, 2021	T105540

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Chemical and Physical Properties

Solubility	Soluble in vegetable oils, alcohol, ether, acetone, fats, and chloroform. Insoluble in water.
Sensitivity	Light sensitive.
Refractive Index	1.505
Flash Point(°F)	235.4 °F
Flash Point(°C)	230°F
Boil Point(°C)	200-220°C
Melt Point(°C)	2.5-3.5°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H317:May cause an allergic skin reaction
WGK Germany	1
RTECS	GA8746000
Reaxy-Rn	1296133
Merck Index	9495

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Caiyun Cheng, Chao Yuan, Bo Cui, Jianpeng Li, Guimei Liu. (2023) β-Cyclodextrin based Pickering emulsions for α-tocopherol delivery: Antioxidation stability and bioaccessibility. FOOD CHEMISTRY, (7): (138000). [PMID:38000154]
2. Qian Zou, Weifei Wang, Qingqing Xu, Menglei Yan, Dongming Lan, Yonghua Wang. (2023) Influence of Proteins on Bioaccessibility of α-Tocopherol Encapsulation within High Diacylglycerol-Based Emulsions. Foods, 12 (13): (2483). [PMID:37444221]
3. Nouman Ali Shah, Rui Hong, Xue Yang, Shi-Shu Huang, Rizwan M. Gul, Yuwei Liu, Lingli Li, Jia-Zhuang Xu, Ka Li, Zhong-Ming Li. (2023) Synergy stabilization of vitamin E and D-sorbitol on crosslinked ultrahigh molecular weight polyethylene for artificial joint under in-vitro clinically relevant accelerated aging. POLYMER DEGRADATION AND STABILITY, 214 (110382). [PMID:]
4. Li Junkui, Zuo Min, Zhang Wen, Zou Xiaobo, Sun Zongbao. (2022) Diazo Coupling-Based Ultrasensitive SERS Detection of Capsaicin and Its Application in Identifying Gutter Oil. Food Analytical Methods, 15 (12): (3468-3478). [PMID:]
5. Xin Wang, Zhi-Jun Zhang, Hui-Zhen Li, Tian-Yu Hou, Ya-Na Zhao, He Li. (2022) Urea complexation combined with rapid preparative reversed-phase liquid chromatography to separate α-linolenic acid from perilla seed oil: Purity, yield, and oxidation stability. INDUSTRIAL CROPS AND PRODUCTS, 187 (115473). [PMID:]
6. Jie Cheng, Hao Qin, Hongye Cheng, Zhen Song, Zhiwen Qi, Kai Sundmacher. (2022) Rational Screening of Deep Eutectic Solvents for the Direct Extraction of α-Tocopherol from Deodorized Distillates. ACS Sustainable Chemistry & Engineering, 10 (25): (8216–8227). [PMID:]
7. Pan Gao, Yunpeng Ding, Zhe Chen, Zhangtao Zhou, Wu Zhong, Chuanrong Hu, Dongping He, Xingguo Wang. (2022) Characteristics and Antioxidant Activity of Walnut Oil Using Various Pretreatment and Processing Technologies. Foods, 11 (12): (1698). [PMID:35741896]
8. Jiang Hong, Fan Yahui, Li Juan, Wang Jiaqi, Kong Liyun, Wang Lina, Li Zhaofang, Ma Mei, Shi Xin, Liu Sijiao, Shi Jia, Zhu Hailu, Liu XiaoHong, Ma Le. (2022) The Associations of Plasma Carotenoids and Vitamins With Risk of Age-Related Macular Degeneration: Results From a Matched Case-Control Study in China and Meta-Analysis. Frontiers in Nutrition, 9 [PMID:35223939]
9. Sheng Zhou, Yuxiu Wen, Yiting Duan, Qi Li, Yuan Gao, Xiuzhu Yu. (2022) Functional Properties and Composition of New “Nut” Oil Obtained from Xanthium sibiricum Seeds. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 124 (4): (2100135). [PMID:]
10. Zihan Xu, Shanshan Liu, Mingyue Shen, Jianhua Xie, Jun Yang. (2022) Evaluation of trans fatty acids, carbonyl compounds and bioactive minor components in commercial linseed oils. FOOD CHEMISTRY, 369 (130930). [PMID:34469834]
11. Ri-Tong Lan, Yue Ren, Xin Wei, Li-Zhi Tang, Nouman Ali Shah, Lu Xu, Shi-Shu Huang, Rizwan M. Gul, Jia-Zhuang Xu, Zhong-Ming Li. (2021) Synergy between vitamin E and D-sorbitol in enhancing oxidation stability of highly crosslinked ultrahigh molecular weight polyethylene. Acta Biomaterialia, 134 (302). [PMID:34311104]
12. Wenjiang Dong, Qiyu Chen, Changqing Wei, Rongsuo Hu, Yuzhou Long, Ying Zong, Zhong Chu. (2021) Comparison of the effect of extraction methods on the quality of green coffee oil from Arabica coffee beans: Lipid yield, fatty acid composition, bioactive components, and antioxidant activity. ULTRASONICS SONOCHEMISTRY, 74 (105578). [PMID:33965776]
13. Liu Shanshan, Hu Huiyu, Yu Yanpeng, Zhao Jiahui, Liu Lichun, Zhao Shanshan, Xie Jianhua, Li Chang, Shen Mingyue. (2021) Simultaneous Determination of Tocopherols, Phytosterols, and Squalene in Vegetable Oils by High Performance Liquid Chromatography-Tandem Mass Spectrometry. Food Analytical Methods, 14 (8): (1567-1576). [PMID:]
14. Fei-Fei Qi, Tian-You Ma, Ya-Meng Fan, Lan-ling Chu, Yan Liu, Yan Yu. (2021) Nanoparticle-based polyacrylonitrile monolithic column for highly efficient micro solid-phase extraction of carotenoids and vitamins in human serum. JOURNAL OF CHROMATOGRAPHY A, 1635 (461755). [PMID:33278673]
15. Liangliang Zhang, Chenyu Liu, Fugui Li, Weihong Qiao. (2020) Performance Improvement of Cleaning Formulations for the Exterior Surface of High-Speed Trains. JOURNAL OF SURFACTANTS AND DETERGENTS, 24 (1): (99-109). [PMID:]
16. Hang Yin, Bohong Du, Yue Chen, Nijia Song, Zhen Li, Jiehua Li, Feng Luo, Hong Tan. (2020) Dual-encapsulated biodegradable 3D scaffold from liposome and waterborne polyurethane for local drug control release in breast cancer therapy. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 31 (17): (2220-2237). [PMID:32663417]
17. Zhang Tiantian, Li Bin, Zhang Xiaoli, Wang Jiao, Wei Longhui, Zhao Binxia, Li Binglin. (2020) 4-Dimethylaminopyridine grafted on MCM-41 as an efficient and highly stable catalyst for the production of α-tocopherol acetate. JOURNAL OF POROUS MATERIALS, 27 (6): (1639-1648). [PMID:]
18. Maiquan Li, Weisu Huang, Fan Jie, Mengmeng Wang, Yongheng Zhong, Qi Chen, Baiyi Lu. (2019) Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking. FOOD AND CHEMICAL TOXICOLOGY, 133 (110758). [PMID:31412289]
19. Dan Chen, Binglin Li, Bin Li, Xiaoli Zhang, Longhui Wei, Wenwen Zheng. (2019) Synthesis of vitamin E succinate catalyzed by nano-SiO2 immobilized DMAP derivative in mixed solvent system. Green Processing and Synthesis, 8 (1): (667-676). [PMID:]
20. Lai Sisi, Wei Yanyan, Wu Quanwu, Zhou Kang, Liu Tuo, Zhang Yingfeng, Jiang Ning, Xiao Wen, Chen Junjie, Liu Qiuhong, Yu Yang. (2019) Liposomes for effective drug delivery to the ocular posterior chamber. JOURNAL OF NANOBIOTECHNOLOGY, 17 (1): (1-12). [PMID:31084611]
21. Cheng Li, Xiao-Lin Qiu, Li-Xin Lu, Ya-Li Tang, Qing Long, Jin-Gui Dang. (2019) Preparation of low-density polyethylene film with quercetin and α-tocopherol loaded with mesoporous silica for synergetic-release antioxidant active packaging. JOURNAL OF FOOD PROCESS ENGINEERING, 42 (5): (e13088). [PMID:]
22. Yue Ren, Xin Wei, Song-Tao Wei, Fei-Yu Wang, Jing Wang, Jia-Zhuang Xu, Lu Xu, Rizwan M. Gul, Zhong-Ming Li. (2019) High Oxidation Stability of Tea Polyphenol-stabilized Highly Crosslinked UHMWPE Under an in Vitro Aggressive Oxidative Condition. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 477 (8): ( 1947–1955). [PMID:31107312]
23. Shulan Xiao, Hong Zhuang, Guanghong Zhou, Jianhao Zhang. (2018) Investigation of inhibition of lipid oxidation by L-carnosine using an oxidized-myoglobin-mediated washed fish muscle system. LWT-FOOD SCIENCE AND TECHNOLOGY, 97 (703). [PMID:]
24. Kaiqiang Wang, Da-Wen Sun, Qingyi Wei, Hongbin Pu. (2018) Quantification and visualization of α-tocopherol in oil-in-water emulsion based delivery systems by Raman microspectroscopy. LWT-FOOD SCIENCE AND TECHNOLOGY, 96 (66). [PMID:]
25. Yu Sun, Yuling Bao, Xue Jiang, Songwei Tan, Mingxing Yin, Conglian Yang, Liping Zhou, Zhiping Zhang. (2018) pH-sensitive micelles with charge-reversible property for tumor growth inhibition and anti-metastasis. Journal of Materials Chemistry B, 6 (3): (458-468). [PMID:32254525]
26. Zhigang Liu, Shihua Yu, Shuping Xu, Bing Zhao, Weiqing Xu. (2017) Ultrasensitive Detection of Capsaicin in Oil for Fast Identification of Illegal Cooking Oil by SERRS. ACS Omega, 2 (11): (8401–8406). [PMID:31457378]
27. Qiaoxian Huang, Jian Chen, Chunjiang Liu, Cheng Wang, Chenghui Shen, Yiyi Chen, Qingyong Li. (2017) Curcumin and its two analogues improve oxidative stability of fish oil under long-term storage. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 119 (10): (1600105). [PMID:]
28. Shi Qiang-Qiang, Dang Jun, Wen Huai-Xiu, Yuan Xiang, Tao Yan-Duo, Wang Qi-Lan. (2016) Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts. Botanical Studies, 57 (1): (1-11). [PMID:28597426]
29. Wenbin Jin, Qiwei Yang, Binbin Huang, Zongbi Bao, Baogen Su, Qilong Ren, Yiwen Yang, Huabin Xing. (2016) Enhanced solubilization and extraction of hydrophobic bioactive compounds using water/ionic liquid mixtures. GREEN CHEMISTRY, 18 (12): (3549-3557). [PMID:]
30. Yuanqing Fu, Yan Zhang, Huiying Hu, Ying Chen, Rong Wang, Duo Li, Songbai Liu. (2014) Design and straightforward synthesis of novel galloyl phytosterols with excellent antioxidant activity. FOOD CHEMISTRY, 163 (171). [PMID:24912713]
31. Xican Li. (2013-07-23) Solvent effects and improvements in the deoxyribose degradation assay for hydroxyl radical-scavenging.. Food chemistry, 141 ((3)): (2083-2088). [PMID:23870931]
32. Yuling Liu,Sai Fu,Longfei Lin,Yuhong Cao,Xi Xie,Hua Yu,Meiwan Chen,Hui Li. (2017-04-25) Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation.. International journal of nanomedicine, 12 (2635-2644). [PMID:28435248]
33. Shudong Zhang,Qiang Wan,Yidan Xing,Jiafeng Ding,Shizhuang Yang,Weiwei Sun,Mengmeng Lu,Baoliang Pan. (2019-01-12) Formulation and Evaluation of a Novel Oral Oil-Based Suspension Using Micro-environmental pH-Modifying Solid Dispersion.. AAPS PharmSciTech, 20 ((2)): (75-75). [PMID:30631975]

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SKU	Size	Availability	Price
T105540-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9.90
T105540-25g	25g	In stock	$24.90
T105540-100g	100g	In stock	$88.90
T105540-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$400.90

DL-α-Tocopherol - 96%, high purity , CAS No.10191-41-0

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