Basic Description

Synonyms	DL-ALPHA-TOCOPHEROL \| 10191-41-0 \| alpha-tochopherol \| Ephanyl \| TOCOPHEROL \| Tocopheroxy radical \| alpha-Tocopherol, DL- \| all-rac-alpha-Tocopherol \| 113085-06-6 \| DL-alpha tocopherol \| Vitamin E DL-alpha \| dl-.alpha.-Tocopherol \| 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl
Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	Tocopherols (vitamin E) comprise of a series (α, β, γ and δ) of chiral compounds that differ by the methylation degree of the phenol moiety of the chromanol ring. They function as lipid soluble antioxidants and protect cell membranes from oxidative damage
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	DL-α-Tocopherol is a physiological membrane-bound antioxidant that protects cell membrane lipids from oxidative damage by free radicals. An antioxidant that protects cell membrane lipids from oxidative damage

Associated Targets(Human)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau (0 Activities)

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PSEN1 Tchem Presenilin-1 (0 Activities)

Discover Target: PSEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PSEN1 Tchem Presenilin 1 (302 Activities)

Discover Target: PSEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Brain (1 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488179662
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179662
IUPAC Name	2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol
INCHI	InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
InChi Key	GVJHHUAWPYXKBD-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
Isomeric SMILES	CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
WGK Germany	1
RTECS	GA8746000
PubChem CID	2116
Molecular Weight	430.71
Beilstein	94012
Reaxy-Rn	1296133

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

17 results found

Lot Number	Certificate Type	Date	Item
L2115670	Certificate of Analysis	Sep 19, 2023	T105540
L2115669	Certificate of Analysis	Sep 19, 2023	T105540
L2115667	Certificate of Analysis	Sep 19, 2023	T105540
D2112026	Certificate of Analysis	Jan 13, 2023	T105540
D2112023	Certificate of Analysis	Jan 13, 2023	T105540
B23111099	Certificate of Analysis	Oct 31, 2022	T105540
B23111104	Certificate of Analysis	Oct 31, 2022	T105540
B23111088	Certificate of Analysis	Oct 31, 2022	T105540
B23111046	Certificate of Analysis	Oct 31, 2022	T105540
E2421063	Certificate of Analysis	Oct 31, 2022	T105540
E2429040	Certificate of Analysis	Oct 31, 2022	T105540
H2304166	Certificate of Analysis	Oct 31, 2022	T105540
B23111075	Certificate of Analysis	Oct 31, 2022	T105540
B23111062	Certificate of Analysis	Oct 31, 2022	T105540
B23111057	Certificate of Analysis	Oct 31, 2022	T105540
H2230037	Certificate of Analysis	Sep 05, 2022	T105540
E2322625	Certificate of Analysis	Nov 18, 2021	T105540

Chemical and Physical Properties

Solubility	Soluble in vegetable oils, alcohol, ether, acetone, fats, and chloroform. Insoluble in water.
Sensitivity	Light sensitive.
Refractive Index	1.505
Flash Point(°F)	235.4 °F
Flash Point(°C)	230°F
Boil Point(°C)	200-220°C
Melt Point(°C)	2.5-3.5°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H317:May cause an allergic skin reaction
WGK Germany	1
RTECS	GA8746000
Reaxy-Rn	1296133
Merck Index	9495

Citations of This Product

1. Caiyun Cheng, Chao Yuan, Bo Cui, Jianpeng Li, Guimei Liu. (2023) β-Cyclodextrin based Pickering emulsions for α-tocopherol delivery: Antioxidation stability and bioaccessibility. FOOD CHEMISTRY, (7): (138000). [PMID:38000154]
2. Qian Zou, Weifei Wang, Qingqing Xu, Menglei Yan, Dongming Lan, Yonghua Wang. (2023) Influence of Proteins on Bioaccessibility of α-Tocopherol Encapsulation within High Diacylglycerol-Based Emulsions. Foods, 12 (13): (2483). [PMID:37444221]
3. Nouman Ali Shah, Rui Hong, Xue Yang, Shi-Shu Huang, Rizwan M. Gul, Yuwei Liu, Lingli Li, Jia-Zhuang Xu, Ka Li, Zhong-Ming Li. (2023) Synergy stabilization of vitamin E and D-sorbitol on crosslinked ultrahigh molecular weight polyethylene for artificial joint under in-vitro clinically relevant accelerated aging. POLYMER DEGRADATION AND STABILITY, 214 (110382). [PMID:]
4. Li Junkui, Zuo Min, Zhang Wen, Zou Xiaobo, Sun Zongbao. (2022) Diazo Coupling-Based Ultrasensitive SERS Detection of Capsaicin and Its Application in Identifying Gutter Oil. Food Analytical Methods, 15 (12): (3468-3478). [PMID:]
5. Xin Wang, Zhi-Jun Zhang, Hui-Zhen Li, Tian-Yu Hou, Ya-Na Zhao, He Li. (2022) Urea complexation combined with rapid preparative reversed-phase liquid chromatography to separate α-linolenic acid from perilla seed oil: Purity, yield, and oxidation stability. INDUSTRIAL CROPS AND PRODUCTS, 187 (115473). [PMID:]
6. Jie Cheng, Hao Qin, Hongye Cheng, Zhen Song, Zhiwen Qi, Kai Sundmacher. (2022) Rational Screening of Deep Eutectic Solvents for the Direct Extraction of α-Tocopherol from Deodorized Distillates. ACS Sustainable Chemistry & Engineering, 10 (25): (8216–8227). [PMID:]
7. Pan Gao, Yunpeng Ding, Zhe Chen, Zhangtao Zhou, Wu Zhong, Chuanrong Hu, Dongping He, Xingguo Wang. (2022) Characteristics and Antioxidant Activity of Walnut Oil Using Various Pretreatment and Processing Technologies. Foods, 11 (12): (1698). [PMID:35741896]
8. Jiang Hong, Fan Yahui, Li Juan, Wang Jiaqi, Kong Liyun, Wang Lina, Li Zhaofang, Ma Mei, Shi Xin, Liu Sijiao, Shi Jia, Zhu Hailu, Liu XiaoHong, Ma Le. (2022) The Associations of Plasma Carotenoids and Vitamins With Risk of Age-Related Macular Degeneration: Results From a Matched Case-Control Study in China and Meta-Analysis. Frontiers in Nutrition, 9 [PMID:35223939]
9. Sheng Zhou, Yuxiu Wen, Yiting Duan, Qi Li, Yuan Gao, Xiuzhu Yu. (2022) Functional Properties and Composition of New “Nut” Oil Obtained from Xanthium sibiricum Seeds. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 124 (4): (2100135). [PMID:]
10. Xican Li. (2013-07-23) Solvent effects and improvements in the deoxyribose degradation assay for hydroxyl radical-scavenging.. Food chemistry, 141 ((3)): (2083-2088). [PMID:23870931]
11. Yuling Liu,Sai Fu,Longfei Lin,Yuhong Cao,Xi Xie,Hua Yu,Meiwan Chen,Hui Li. (2017-04-25) Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation.. International journal of nanomedicine, 12 (2635-2644). [PMID:28435248]
12. Shudong Zhang,Qiang Wan,Yidan Xing,Jiafeng Ding,Shizhuang Yang,Weiwei Sun,Mengmeng Lu,Baoliang Pan. (2019-01-12) Formulation and Evaluation of a Novel Oral Oil-Based Suspension Using Micro-environmental pH-Modifying Solid Dispersion.. AAPS PharmSciTech, 20 ((2)): (75-75). [PMID:30631975]

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DL-α-Tocopherol - 96%, high purity , CAS No.10191-41-0