Basic Description

Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Product Description	Shipped at Room Temperature. Store at -20°C long term. Store under desiccating conditions.

Associated Targets(Human)

LIG1 Tchem DNA ligase 1 (1 Activities)

Discover Target: LIG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PCNA Tchem Proliferating cell nuclear antigen (1 Activities)

Discover Target: PCNA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

U2OS (164939 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LIG1 Tchem DNA ligase 1 (262 Activities)

Discover Target: LIG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol
INCHI	InChI=1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1
InChi Key	NKOSKXJRVWVXRI-JTQLQIEISA-N
Canonical SMILES	C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(CO)N)I
Isomeric SMILES	C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)C[C@@H](CO)N)I
PubChem CID	71185540
Molecular Weight	511.09

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
K2420064	Certificate of Analysis	May 16, 2024	T275562
J2225650	Certificate of Analysis	Aug 22, 2023	T275562
J2225655	Certificate of Analysis	Aug 22, 2023	T275562
J2225693	Certificate of Analysis	Aug 22, 2023	T275562
J2225701	Certificate of Analysis	Aug 22, 2023	T275562
J2225734	Certificate of Analysis	Aug 22, 2023	T275562

Chemical and Physical Properties

Solubility	Soluble in DMSO to 100 mM

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P304+P340+P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing.Call a POISON CENTER or doctor. if you feel unwell.

References

1. Ma J et al.. (2020) BARX2 expression is downregulated by CpG island hypermethylation and is associated with suppressed cell proliferation and invasion of gastric cancer cells.. Oncol Rep, 43 (6): (1805-1818). [PMID:32236603]

Solution Calculators

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SKU	Size	Availability	Price
T275562-5mg	5mg	In stock	$107.90
T275562-10mg	10mg	In stock	$172.90
T275562-25mg	25mg	In stock	$365.90
T275562-50mg	50mg	In stock	$583.90
T275562-100mg	100mg	In stock	$929.90

T2AA - ≥98%, high purity , CAS No.1380782-27-3