tacrolimus|Fujimycin|104987-11-3|Prograf|Tsukubaenolide|Protopic|Tacrolimus anhydrous|FK506|Advagraf|Modigraf|Anhydrous Tacrolimus|Prograft|Fk-506|Protopy|LCP-Tacro|FK 506|Avagraf|Envarsus|FR-900506|tacrolimus (fk506)|Astagraf XL|Envarsus XR|Tacrolimus, a
Specifications & Purity
analytical standard, ≥98%
Biochemical and Physiological Mechanisms
Description: IC50 Value: 0.47 nM (Inhibition of lymphocyte proliferation) [1] Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. in vit
Storage Temp
Store at -20°C
Shipped In
Dry ice
Grade
analytical standard, Moligand™
Action Type
ACTIVATOR, INHIBITOR
Mechanism of action
Inhibitor of FKBP prolyl isomerase 1A;Activator of TRPM8
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Rojanathammanee L et al.. (2015) Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition.. J Neuroinflammation, 12 (42). [PMID:25889879]
2.Winther ÅM et al.. (2015) An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction.. J Neurosci, 35 (44):(14756-70). [PMID:26538647]
3.Morillon YM et al.. (2016) Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration.. J Immunol, 197 (9):(3504-3511). [PMID:27694496]
4.Jensen T & Edwards JG. (2012) Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons.. Neurosci Lett, 510 (2):(82-7). [PMID:22260796]
5.Pramme-Steinwachs I et al.. (2017) Extracellular calcium modulates brown adipocyte differentiation and identity.. Sci Rep, 7 (8888). [PMID:28827782]
6.Cohen A et al.. (2014) Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.. J Biol Chem, 289 (31):(21727-37). [PMID:24928510]
7.Wang H et al.. (2020) Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.. Autophagy, 16 (9):(1683-1696). [PMID:31826695]
8.Huang TQ et al.. (2017) Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury.. Mol Med Rep, 15 (5):(3001-3010). [PMID:28339015]
9.Ilmarinen T et al.. (2019) Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.. Acta Ophthalmol, 97 (5):(e688-e699). [PMID:30593729]
10.Di Campli MP et al.. (2021) The mononuclear phagocyte system contributes to fibrosis in post-transplant obliterans bronchiolitis.. Eur Respir J, 57 (3):[PMID:33033147]
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