Basic Description

Synonyms	tacrolimus\|Fujimycin\|104987-11-3\|Prograf\|Tsukubaenolide\|Protopic\|Tacrolimus anhydrous\|FK506\|Advagraf\|Modigraf\|Anhydrous Tacrolimus\|Prograft\|Fk-506\|Protopy\|LCP-Tacro\|FK 506\|Avagraf\|Envarsus\|FR-900506\|tacrolimus (fk506)\|Astagraf XL\|Envarsus XR\|Tacrolimus, a
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A5 Tclin Cytochrome P450 3A5 0 Activities

Discover Target: CYP3A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FKBP1A Tclin Peptidyl-prolyl cis-trans isomerase FKBP1A 1 Activities

Discover Target: FKBP1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FKBP1B Tchem Peptidyl-prolyl cis-trans isomerase FKBP1B 0 Activities

Discover Target: FKBP1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FKBP5 Tchem Peptidyl-prolyl cis-trans isomerase FKBP5 0 Activities

Discover Target: FKBP5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SF3B3 Tchem Splicing factor 3B subunit 3 0 Activities

Discover Target: SF3B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPP3CA Tchem Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 0 Activities

Discover Target: PPP3CA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR 0 Activities

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488189839
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488189839
IUPAC Name	(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
INCHI	InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
InChi Key	QJJXYPPXXYFBGM-LFZNUXCKSA-N
Canonical SMILES	CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
Isomeric SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
WGK Germany	3
RTECS	KD4201200
PubChem CID	445643
UN Number	2811
Molecular Weight	804.02

Database links

PubChem SID	488189839

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

16 results found

Lot Number	Certificate Type	Date	Item
D2412339	Certificate of Analysis	Apr 24, 2024	T101160
D2412341	Certificate of Analysis	Apr 24, 2024	T101160
D2412343	Certificate of Analysis	Apr 24, 2024	T101160
D2424417	Certificate of Analysis	Mar 08, 2024	T101160
D2424419	Certificate of Analysis	Mar 08, 2024	T101160
C2328969	Certificate of Analysis	Apr 15, 2023	T101160
C2328970	Certificate of Analysis	Apr 15, 2023	T101160
C2328971	Certificate of Analysis	Apr 15, 2023	T101160
C2328988	Certificate of Analysis	Apr 15, 2023	T101160
C2328989	Certificate of Analysis	Apr 15, 2023	T101160
C2328990	Certificate of Analysis	Apr 15, 2023	T101160
D2411064	Certificate of Analysis	Apr 15, 2023	T101160
C2224038	Certificate of Analysis	May 03, 2022	T101160
E2128036	Certificate of Analysis	May 28, 2021	T101160
G2220848	Certificate of Analysis	May 28, 2021	T101160
G2220849	Certificate of Analysis	May 28, 2021	T101160

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 80.4, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 80.4, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	KD4201200

FAQs and Articles

FAQ

Metabolic signaling pathway

Categories: Technical articles

Tags:

Carbohydrate metabolism Lipid metabolism Glutamic acid metabolism Nucleotide metabolism

Solution Calculators

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SKU	Size	Availability	Price
T101160-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$21.90
T101160-50mg	50mg	In stock	$82.90
T101160-250mg	250mg	In stock	$373.90
T101160-1g	1g	In stock	$1,344.90

Tacrolimus - ≥98%, high purity , CAS No.104987-11-3