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Tacrolimus - ≥98%, high purity , CAS No.104987-11-3

6 Citations
Item Number
T101160
Grouped product items
SKUSizeAvailabilityPrice Qty
T101160-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$21.90
T101160-50mg
50mg
In stock
$82.90
T101160-250mg
250mg
In stock
$373.90
T101160-1g
1g
In stock
$1,344.90
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Potent calcineurin inhibitor; immunosuppressant

Basic Description

Synonyms(7aR)-4,4,7a-trimethyl-6,7-dihydro-5H-benzofuran-2-one;Dihydroactinidiolide | CHEBI:93221 | DB00864 | HMS1792O21 | UNII-WM0HAQ4WNM | FR900506 | FR-900506 | Modigraf | NCGC00163470-05 | NSC758659 | NSC-758659 | HY-100943 | L-679934 | M2258 | AM81227 | L04A
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A5 Tclin Cytochrome P450 3A5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FKBP1A Tclin Peptidyl-prolyl cis-trans isomerase FKBP1A (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FKBP1B Tchem Peptidyl-prolyl cis-trans isomerase FKBP1B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FKBP5 Tchem Peptidyl-prolyl cis-trans isomerase FKBP5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SF3B3 Tchem Splicing factor 3B subunit 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPP3CA Tchem Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MTOR Tclin Serine/threonine-protein kinase mTOR (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488189839
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189839
IUPAC Name (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
INCHI InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
InChi Key QJJXYPPXXYFBGM-LFZNUXCKSA-N
Canonical SMILES CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
Isomeric SMILES C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
WGK Germany 3
RTECS KD4201200
PubChem CID 445643
UN Number 2811
Molecular Weight 804.02

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
D2412339Certificate of AnalysisApr 24, 2024 T101160
D2412341Certificate of AnalysisApr 24, 2024 T101160
D2412343Certificate of AnalysisApr 24, 2024 T101160
D2424417Certificate of AnalysisMar 08, 2024 T101160
D2424419Certificate of AnalysisMar 08, 2024 T101160
C2328969Certificate of AnalysisApr 15, 2023 T101160
C2328970Certificate of AnalysisApr 15, 2023 T101160
C2328971Certificate of AnalysisApr 15, 2023 T101160
C2328988Certificate of AnalysisApr 15, 2023 T101160
C2328989Certificate of AnalysisApr 15, 2023 T101160
C2328990Certificate of AnalysisApr 15, 2023 T101160
D2411064Certificate of AnalysisApr 15, 2023 T101160
C2224038Certificate of AnalysisMay 03, 2022 T101160
E2128036Certificate of AnalysisMay 28, 2021 T101160
G2220848Certificate of AnalysisMay 28, 2021 T101160
G2220849Certificate of AnalysisMay 28, 2021 T101160

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 80.4, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 80.4, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS KD4201200

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Metabolic signaling pathway
Categories: Technical articles
Tags:
Carbohydrate metabolism Lipid metabolism Glutamic acid metabolism Nucleotide metabolism

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Feng Chen, Xiaoxia Yang, Huanhuan Li, Xiaodan Zeng, Ziwei Deng, Hongqiang Wang, Yuanxiang Jin, Chengfeng Qiu, Zhihua Shi.  (2023)  Improved LC–MS/MS method for the simultaneous quantification of tacrolimus and cyclosporine A in human blood and application to therapeutic drug monitoring.  BIOMEDICAL CHROMATOGRAPHY,  37  (12): (e5751).  [PMID:37772369]
2. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu.  (2023)  A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood.  Journal of Materials Chemistry B,  11  (20): (4464-4474).  [PMID:37159048]
3. Fei Gong, Huihui Hu, Ying Ouyang, Zheng-Zheng Liao, Ying Kong, Jin-Fang Hu, Hua He, Ying Zhou.  (2023)  Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles.  TOXICOLOGY AND APPLIED PHARMACOLOGY,  466  (116475).  [PMID:36931438]
4. Wang Hongkang, Ji Zhe, Feng Yanru, Yan Tianhua, Cao Yongbing, Lu Hui, Jiang Yuanying.  (2022)  Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1.  Frontiers in Pharmacology,  13    [PMID:36618949]
5. Qingfeng He, Fengjiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhijia Tang, Wen Yao Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang.  (2022)  Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (9): (4485).  [PMID:35562875]
6. Gao Ping, Du Xiaoyi, Liu Lili, Xu Hua, Liu Maochang, Guan Xinlei, Zhang Chengliang.  (2021)  Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway.  Frontiers in Pharmacology,  11    [PMID:33536919]
7. Shoubao Wang, Yao Xiong, Yinmin Wang, Jingting Chen, Jun Yang, Binbin Sun.  (2020)  Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study.  TRANSPLANT INTERNATIONAL,  33  (4): (450-461).  [PMID:31930539]
8. Y. Chen, Y. Yang, F. Wang, X. Yang, F. Yao, K. Ming, W. Yuan, L. Zeng, J. Liu.  (2018)  Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1.  POULTRY SCIENCE,  97  (2722).  [PMID:29757435]
9. Yun Chen,Ling Zeng,Wen Xiong,Meiyun Song,Hongxu Du,Yixuan Wang,Ke Ming,Yi Wu,Deyun Wang,Yuanliang Hu,Jiaguo Liu.  (2015-04-23)  Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments..  Virus research,  204  (58-67).  [PMID:25901935]

References

1. Feng Chen, Xiaoxia Yang, Huanhuan Li, Xiaodan Zeng, Ziwei Deng, Hongqiang Wang, Yuanxiang Jin, Chengfeng Qiu, Zhihua Shi.  (2023)  Improved LC–MS/MS method for the simultaneous quantification of tacrolimus and cyclosporine A in human blood and application to therapeutic drug monitoring.  BIOMEDICAL CHROMATOGRAPHY,  37  (12): (e5751).  [PMID:37772369]
2. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu.  (2023)  A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood.  Journal of Materials Chemistry B,  11  (20): (4464-4474).  [PMID:37159048]
3. Fei Gong, Huihui Hu, Ying Ouyang, Zheng-Zheng Liao, Ying Kong, Jin-Fang Hu, Hua He, Ying Zhou.  (2023)  Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles.  TOXICOLOGY AND APPLIED PHARMACOLOGY,  466  (116475).  [PMID:36931438]
4. Wang Hongkang, Ji Zhe, Feng Yanru, Yan Tianhua, Cao Yongbing, Lu Hui, Jiang Yuanying.  (2022)  Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1.  Frontiers in Pharmacology,  13    [PMID:36618949]
5. Qingfeng He, Fengjiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhijia Tang, Wen Yao Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang.  (2022)  Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (9): (4485).  [PMID:35562875]
6. Gao Ping, Du Xiaoyi, Liu Lili, Xu Hua, Liu Maochang, Guan Xinlei, Zhang Chengliang.  (2021)  Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway.  Frontiers in Pharmacology,  11    [PMID:33536919]
7. Shoubao Wang, Yao Xiong, Yinmin Wang, Jingting Chen, Jun Yang, Binbin Sun.  (2020)  Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study.  TRANSPLANT INTERNATIONAL,  33  (4): (450-461).  [PMID:31930539]
8. Y. Chen, Y. Yang, F. Wang, X. Yang, F. Yao, K. Ming, W. Yuan, L. Zeng, J. Liu.  (2018)  Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1.  POULTRY SCIENCE,  97  (2722).  [PMID:29757435]
9. Yun Chen,Ling Zeng,Wen Xiong,Meiyun Song,Hongxu Du,Yixuan Wang,Ke Ming,Yi Wu,Deyun Wang,Yuanliang Hu,Jiaguo Liu.  (2015-04-23)  Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments..  Virus research,  204  (58-67).  [PMID:25901935]

Solution Calculators

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