Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T125358-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
T125358-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $16.90 | |
T125358-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $19.90 | |
T125358-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $26.90 | |
T125358-1g | 1g | In stock | $29.90 | |
T125358-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $79.90 | |
T125358-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $225.90 | |
T125358-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $639.90 |
Potent and highly selective PDE5 inhibitor
Synonyms | Tadalafil|Cialis|171596-29-5|Ic351|Tadanafil|ADCIRCA|ICOS 351|IC 351|IC-351|Tadalafil mylan|Trans-tadalafil|Tadalafil Lilly|GF 196960|Tadalafilo|(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1, |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Potent and highly selective PDE5 inhibitor (IC50= 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibi |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Phosphodiesterase 5A inhibitor |
Note | 50mg/100mg/500mg 售完停产 |
Product Description | Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. |
ALogP | 2.3 |
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IUPAC Name | (2R,8R)-2-(1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
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INCHI | InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 |
InChi Key | WOXKDUGGOYFFRN-IIBYNOLFSA-N |
Canonical SMILES | CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36 |
Isomeric SMILES | CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36 |
WGK Germany | 2 |
RTECS | UQ4431050 |
PubChem CID | 110635 |
Molecular Weight | 389.4 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2427055 | Certificate of Analysis | Jul 02, 2024 | T125358 |
G2429143 | Certificate of Analysis | Jun 14, 2024 | T125358 |
G2429144 | Certificate of Analysis | Jun 14, 2024 | T125358 |
H2401477 | Certificate of Analysis | Jun 14, 2024 | T125358 |
H2401478 | Certificate of Analysis | Jun 14, 2024 | T125358 |
J2324019 | Certificate of Analysis | Sep 19, 2023 | T125358 |
L2107007 | Certificate of Analysis | Sep 19, 2023 | T125358 |
L2107088 | Certificate of Analysis | Sep 19, 2023 | T125358 |
L2107091 | Certificate of Analysis | Sep 19, 2023 | T125358 |
K1526087 | Certificate of Analysis | May 11, 2023 | T125358 |
D1521032 | Certificate of Analysis | Nov 16, 2022 | T125358 |
H2003123 | Certificate of Analysis | Jun 13, 2022 | T125358 |
H2003122 | Certificate of Analysis | Jun 13, 2022 | T125358 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 38.94, Max Conc. mM: 100 |
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Sensitivity | Air sensitive; Heat sensitive |
Flash Point(°F) | 35.6 °F |
Flash Point(°C) | 35.6°F |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | UQ4431050 |
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1. Forgue ST, Patterson BE, Bedding AW, Payne CD, Phillips DL, Wrishko RE, Mitchell MI. (2006) Tadalafil pharmacokinetics in healthy subjects.. Br J Clin Pharmacol, 61 (3): (280-8). [PMID:16487221] |