TAK-828F , CAS No.T614319, Agonist of RAR-related orphan receptor-γ

Item Number
T614319
Grouped product items
SKUSizeAvailabilityPrice Qty
T614319-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$996.90
T614319-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,986.90

Basic Description

Synonymscompound 10;TAK-828;TAK828F
Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of RAR-related orphan receptor-γ

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[3-[(5R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydroinden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]cyclobutyl]acetic acid
INCHI InChI=1S/C28H32FN3O5/c1-28(2)8-6-16-13-18(14-20(29)24(16)28)30-26(35)25-19-4-5-22(37-3)31-21(19)7-9-32(25)27(36)17-10-15(11-17)12-23(33)34/h4-5,13-15,17,25H,6-12H2,1-3H3,(H,30,35)(H,33,34)/t15-,17+,25-/m1/s1
InChi Key ICMFYVOUDGRBLG-VFHHBZAHSA-N
Canonical SMILES COc1ccc2c(n1)CCN([C@H]2C(=O)Nc1cc(F)c2c(c1)CCC2(C)C)C(=O)[C@@H]1C[C@@H](C1)CC(=O)O
Isomeric SMILES CC1(CCC2=C1C(=CC(=C2)NC(=O)[C@H]3C4=C(CCN3C(=O)C5CC(C5)CC(=O)O)N=C(C=C4)OC)F)C
PubChem CID 118622692

Certificates

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Related Documents

References

1. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT et al..  (1999)  IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis..  J Clin Invest,  103  (9): (1345-52).  [PMID:10225978] [10.1021/op500134e]
2. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR.  (2006)  The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells..  Cell,  126  (6): (1121-33).  [PMID:16990136] [10.1021/op500134e]
3. Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza GR, Monteleone G, Di Sabatino A, Macdonald TT.  (2009)  Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease..  Gut,  58  (12): (1629-36).  [PMID:19740775] [10.1021/op500134e]
4. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ et al..  (2009)  Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways..  Nat Genet,  41  (2): (199-204).  [PMID:19169254] [10.1021/op500134e]
5. Kebir H, Ifergan I, Alvarez JI, Bernard M, Poirier J, Arbour N, Duquette P, Prat A.  (2009)  Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis..  Ann Neurol,  66  (3): (390-402).  [PMID:19810097] [10.1021/op500134e]
6. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Filì L, Ferri S, Frosali F et al..  (2007)  Phenotypic and functional features of human Th17 cells..  J Exp Med,  204  (8): (1849-61).  [PMID:17635957] [10.1021/op500134e]
7. Wilke CM, Bishop K, Fox D, Zou W.  (2011)  Deciphering the role of Th17 cells in human disease..  Trends Immunol,  32  (12): (603-11).  [PMID:21958759] [10.1021/op500134e]
8. Miossec P, Kolls JK.  (2012)  Targeting IL-17 and TH17 cells in chronic inflammation..  Nat Rev Drug Discov,  11  (10): (763-76).  [PMID:23023676] [10.1021/op500134e]
9. Campa M, Mansouri B, Warren R, Menter A.  (2016)  A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis..  Dermatol Ther (Heidelb),  (1): (1-12).  [PMID:26714681] [10.1021/op500134e]
10. Beringer A, Noack M, Miossec P.  (2016)  IL-17 in Chronic Inflammation: From Discovery to Targeting..  Trends Mol Med,  22  (3): (230-241).  [PMID:26837266] [10.1021/op500134e]
11. Shibata A, Uga K, Sato T, Sagara M, Igaki K, Nakamura Y, Ochida A, Kono M, Shirai J, Yamamoto S et al..  (2018)  Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist..  Biochem Pharmacol,  150  (13): (35-45).  [PMID:29369782] [10.1021/op500134e]
12. Kono M, Ochida A, Oda T, Imada T, Banno Y, Taya N, Masada S, Kawamoto T, Yonemori K, Nara Y et al..  (2018)  Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist..  J Med Chem,  61  (7): (2973-2988).  [PMID:29510038] [10.1021/op500134e]

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