Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T126322-1mg | 1mg | In stock | $18.90 | |
T126322-5mg | 5mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $78.90 | |
T126322-10mg | 10mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $127.90 | |
T126322-50mg | 50mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $464.90 |
Synonyms | 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide | NCGC00346645-04 | TAK901 | TAK-901 | NCGC00346645-05 | TAK 901 | Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | TAK-901 is a potent and tight-binding Aurora B kinase inhibitor. TAK-901 targets multiple kinases in vitro, but appears to mainly target Aurora B in cells and in vivo. TAK-901 suppresses cellular histone H3 phosphorylation and induced polyploidy. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Serine/threonine-protein kinase Aurora-B inhibitor |
Product Description | Product Describtion: TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively. |
ALogP | 4.5 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488199045 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488199045 |
IUPAC Name | 5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide |
INCHI | InChI=1S/C28H32N4O3S/c1-5-36(34,35)21-8-6-7-19(14-21)23-15-22(28(33)30-20-9-11-32(4)12-10-20)18(3)26-25(23)24-13-17(2)16-29-27(24)31-26/h6-8,13-16,20H,5,9-12H2,1-4H3,(H,29,31)(H,30,33) |
InChi Key | WKDACQVEJIVHMZ-UHFFFAOYSA-N |
Canonical SMILES | CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C |
Isomeric SMILES | CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C |
PubChem CID | 16124208 |
Molecular Weight | 504.66 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C23021256 | Certificate of Analysis | Dec 11, 2024 | T126322 |
C23021270 | Certificate of Analysis | Dec 11, 2024 | T126322 |
C2303002 | Certificate of Analysis | Dec 11, 2024 | T126322 |
C2303006 | Certificate of Analysis | Dec 11, 2024 | T126322 |
C23311361 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311362 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311363 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311368 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311373 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311374 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311375 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C23311380 | Certificate of Analysis | Dec 09, 2022 | T126322 |
C2301256 | Certificate of Analysis | Dec 09, 2022 | T126322 |
Solubility | DMSO: 2 mg/mL, clear (warmed) |
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