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Talampanel - ≥98%(HPLC), high purity , Glutamate receptor ionotropic, AMPA 1 antagonist, CAS No.161832-65-1, Glutamate receptor ionotropic, AMPA 1 antagonist

Moligand™

≥98%(HPLC)

CAS#: 161832-65-1
Formula: C₁₉H₁₉N₃O₃
Molecular Weight: 337.37
PubChem CID: 164509

Item Number

T287576

Grouped product items
SKU	Size	Availability	Price	Qty
T287576-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$155.90

Non-competitive non-NMDA iGluR antagonist

View related series

GluA2 Antagonist

Basic Description

Synonyms	Talampanel \| 161832-65-1 \| Ampanel \| GYKI 53773 \| Kinampa \| LY-300164 \| GYKI-53773 \| LY 300164 \| Talampanel (INN) \| Talampanel [INN] \| (-)-Talampanel \| (8R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine \| LY300164 \| 1-[(8R)-5-(4-aminophen
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity thanGYKI 52466. Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Glutamate receptor ionotropic, AMPA 1 antagonist

Associated Targets(Human)

GRIA2 Tclin Glutamate receptor 2 (0 Activities)

Discover Target: GRIA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gallus gallus (1187 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meriones unguiculatus (417 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
INCHI	InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
InChi Key	JACAAXNEHGBPOQ-LLVKDONJSA-N
Canonical SMILES	CC1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
Isomeric SMILES	C[C@@H]1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
WGK Germany	3
PubChem CID	164509
Molecular Weight	337.37

Wikipedia

PubChem CID

ChEMBL Ligand

DrugBank Ligand

CAS Registry No.

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RIDADR	UN2811-class6.1-PG3-EHS-Toxicsolids，organic，n.o.s.，HI:all

References

1. Aujla PK, Fetell MR, Jensen FE. (2009) Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.. Epilepsia, 50 (4): (694-701). [PMID:19220413]
2. Wang C, Niu L. (2013) Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives.. ACS Chem Neurosci, 4 (4): (635-44). [PMID:23402301]

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Talampanel - ≥98%(HPLC), high purity , Glutamate receptor ionotropic, AMPA 1 antagonist, CAS No.161832-65-1, Glutamate receptor ionotropic, AMPA 1 antagonist

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

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