Skip to the beginning of the images gallery

Talarozole - ≥99%, high purity , CAS No.201410-53-9, Inhibitor of CYP26A1

Moligand™

≥99%

CAS#: 201410-53-9
Formula: C₂₁H₂₃N₅S
Molecular Weight: 377.51
PubChem CID: 9799888

Item Number

T126654

Grouped product items
SKU	Size	Availability	Price
T126654-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$165.90
T126654-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$212.90
T126654-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$474.90

View related series

CYP26A1 Inhibitor

Basic Description

Synonyms	Talarozole \| 201410-53-9 \| Rambazole \| R115866 \| R-115866 \| N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine \| 201410-66-4 \| (+)-Talarozole \| XKD9N5CJ6W \| N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine \| CHEMBL459505 \| 2-B
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Description: IC50 Value:N/A Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne[2]. in vitro: Talarozole treatment increased
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of CYP26A1

Associated Targets(Human)

CYP26A1 Tchem Cytochrome P450 26A1 (1 Activities)

Discover Target: CYP26A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP26B1 Tchem Cytochrome P450 26B1 (1 Activities)

Discover Target: CYP26B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP26A1 Tchem Cytochrome P450 26A1 (308 Activities)

Discover Target: CYP26A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP26B1 Tchem Cytochrome P450 26B1 (25 Activities)

Discover Target: CYP26B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine
INCHI	InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)
InChi Key	SNFYYXUGUBUECJ-UHFFFAOYSA-N
Canonical SMILES	CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4
Isomeric SMILES	CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4
PubChem CID	9799888
Molecular Weight	377.51

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

References

1. Verfaille CJ, Thissen CA, Bovenschen HJ, Mertens J, Steijlen PM, van de Kerkhof PC. (2007) Oral R115866 in the treatment of moderate to severe plaque-type psoriasis.. J Eur Acad Dermatol Venereol, 21 (8): (1038-46). [PMID:17714122]
2. Verfaille CJ, Coel M, Boersma IH, Mertens J, Borgers M, Roseeuw D. (2007) Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study.. Br J Dermatol, 157 (1): (122-6). [PMID:17459036]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Talarozole - ≥99%, high purity , CAS No.201410-53-9, Inhibitor of CYP26A1

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator