Basic Description

Synonyms	AKOS030214485 \| CCG-264948 \| Q27131658 \| BCPP000052 \| 1H7BKF44U1 \| Methyl P-toluenesulfonyl-L-argininate \| s2225 \| FKMJXALNHKIDOD-LBPRGKRZSA-N \| HY-13255 \| BDBM50070707 \| SCHEMBL324561 \| Tame \| ARGININE, N2-(P-TOLYLSULFONYL)-, METHYL ESTER, L- \| N(alpha)-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate
INCHI	InChI=1S/C14H22N4O4S/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17)/t12-/m0/s1
InChi Key	FKMJXALNHKIDOD-LBPRGKRZSA-N
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC
Isomeric SMILES	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)OC
PubChem CID	1550286
Molecular Weight	342.41

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
B2222549	Certificate of Analysis	Feb 28, 2022	T126267
B2223036	Certificate of Analysis	Feb 28, 2022	T126267
B2223047	Certificate of Analysis	Feb 28, 2022	T126267

Chemical and Physical Properties

Solubility	DMSO 69 mg/mL Water 69 mg/mL Ethanol 3 mg/mL

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yiyang Chen, Hao Ren, Xiangyu Kong, Hao Wu, Zhenmei Lu. (2023) A multicomponent propane monooxygenase catalyzes the initial degradation of methyl tert-butyl ether in Mycobacterium vaccae JOB5. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (1): [PMID:37823642]
2. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046]
3. Liu Ting, Chen Xiaopeng, Xing Jinfeng, Ge Zhiqiang. (2018) Effects of acetazolamide on the conformations and activities of digestive enzymes: pepsin and trypsin. MEDICINAL CHEMISTRY RESEARCH, 27 (5): (1549-1557). [PMID:]
4. Xiong Zheng, Ying Zhang, Maogang He. (2016) Speed of sound measurement in ethyl tert-butyl ether and tert-amyl methyl ether by Brillouin light scattering. FLUID PHASE EQUILIBRIA, 418 (108). [PMID:]

References

1. Yiyang Chen, Hao Ren, Xiangyu Kong, Hao Wu, Zhenmei Lu. (2023) A multicomponent propane monooxygenase catalyzes the initial degradation of methyl tert-butyl ether in Mycobacterium vaccae JOB5. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (1): [PMID:37823642]
2. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046]
3. Liu Ting, Chen Xiaopeng, Xing Jinfeng, Ge Zhiqiang. (2018) Effects of acetazolamide on the conformations and activities of digestive enzymes: pepsin and trypsin. MEDICINAL CHEMISTRY RESEARCH, 27 (5): (1549-1557). [PMID:]
4. Xiong Zheng, Ying Zhang, Maogang He. (2016) Speed of sound measurement in ethyl tert-butyl ether and tert-amyl methyl ether by Brillouin light scattering. FLUID PHASE EQUILIBRIA, 418 (108). [PMID:]

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SKU	Size	Availability	Price
T126267-5mg	5mg	In stock	$9.90
T126267-10mg	10mg	In stock	$12.90
T126267-50mg	50mg	In stock	$52.90

TAME - ≥99%, high purity , CAS No.901-47-3