Basic Description

Synonyms	TAN-67 \| SB-213698 \| CHEMBL327745 \| 148545-09-9 \| 3-[(4aS,12aR)-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a-yl]phenol \| (3-HYDROXYPHENYL)-1,2,3,4,4A,5,12,12AA-OCTAHYDROQUINOLINO[2,3,3-G]ISOQUINOLINE DIHYDROBROMIDE \| UY7TB22PB7 \| SB-205607 \| GTPL9567 \| SCHEMBL1
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of δ receptor;Agonist of MRGPRX2

Associated Targets(Human)

OPRD1 Tclin Delta-type opioid receptor (4 Activities)

Discover Target: OPRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MRGPRX2 Tchem Mas-related G-protein coupled receptor member X2 (1 Activities)

Discover Target: MRGPRX2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRK1 Tclin Kappa opioid receptor (16155 Activities)

Discover Target: OPRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DHCR24 Tchem Delta(24)-sterol reductase (295 Activities)

Discover Target: DHCR24

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-[(4aS,12aR)-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a-yl]phenol
INCHI	InChI=1S/C23H24N2O/c1-25-10-9-23(18-6-4-7-20(26)13-18)14-22-17(12-19(23)15-25)11-16-5-2-3-8-21(16)24-22/h2-8,11,13,19,26H,9-10,12,14-15H2,1H3/t19-,23+/m0/s1
InChi Key	LEPBHAAYNPPRRA-WMZHIEFXSA-N
Canonical SMILES	CN1CC[C@]2([C@H](C1)Cc1c(C2)nc2c(c1)cccc2)c1cccc(c1)O
Isomeric SMILES	CN1CC[C@@]2(CC3=NC4=CC=CC=C4C=C3C[C@H]2C1)C5=CC(=CC=C5)O
PubChem CID	9950038

Database links

PubChem CID	9950038
ChEMBL Ligand	CHEMBL327745
BindingDB Ligand	50290872
GPCRdb Ligand	TAN-67

Certificates

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References

1. Fujii H, Kawai K, Kawamura K, Mizusuna A, Onoda Y, Murachi M, Tanaka T, Endoh T, Nagase H. (2001) Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties.. Drug Des Discov, 17 (4): (325-30). [PMID:11765135]
2. Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J et al.. (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2.. Nat Chem Biol, 13 (5): (529-536). [PMID:28288109]

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SKU	Size	Availability	Price	Qty
T614330-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$674.90
T614330-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,020.90

TAN-67 , CAS No.T614330, Agonist of δ receptor;Agonist of MRGPRX2