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Tandutinib (MLN518) - ≥98%, high purity , Platelet-derived growth factor receptor beta inhibitor, CAS No.387867-13-2, Platelet-derived growth factor receptor beta inhibitor

Moligand™
≥98%

CAS#: 387867-13-2
Formula: C₃₁H₄₂N₆O₄
Molecular Weight: 562.72
PubChem CID: 3038522

Item Number

T125150

Grouped product items
SKU	Size	Availability	Price
T125150-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$31.90
T125150-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$103.90
T125150-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$468.90

View related series

colony stimulating factor 1 receptor Inhibitor fms related receptor tyrosine kinase 3 Inhibitor KIT proto-oncogene，receptor tyrosine kinase Inhibitor platelet derived growth factor receptor beta Inhibitor

Basic Description

Synonyms	Tandutinib\|387867-13-2\|MLN-518\|CT53518\|MLN518\|Tandutinib (MLN518)\|MLN 518\|CT 53518\|CT-53518\|N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide\|4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyro
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Platelet-derived growth factor receptor beta inhibitor
Note	卖完停产，不再备货
Product Description	Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. A piperazinyl quinazoline receptor tyrosine kinase inhibitor

Names and Identifiers

IUPAC Name	4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
INCHI	InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
InChi Key	UXXQOJXBIDBUAC-UHFFFAOYSA-N
Canonical SMILES	CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5
Isomeric SMILES	CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5
PubChem CID	3038522
Molecular Weight	562.72

CAS Registry No.

387867-13-2

DiscoveRx TREEspot

MLN-518|

PubChem CID

66524380

Reactome Reaction

R-HSA-9702510, R-HSA-9695831, R-HSA-9702638

Reactome Drug

R-ALL-9695994

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Lot Number	Certificate Type	Date	Item
G1706080	Certificate of Analysis	Feb 06, 2023	T125150

Solubility

Soluble in water (very poorly), DMSO (25 mg/ml, with slight warming), ethanol (25 mg/ml, with slight warming), and chloroform.

Melt Point(°C)

172-183°C

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Tandutinib (MLN518) - ≥98%, high purity , Platelet-derived growth factor receptor beta inhibitor, CAS No.387867-13-2, Platelet-derived growth factor receptor beta inhibitor

Basic Description

Product Properties

Names and Identifiers

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Certificate of Analysis(COA)

Chemical and Physical Properties

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