Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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T123655-25mg | 25mg | In stock | $36.90 | |
T123655-50mg | 50mg | In stock | $59.90 | |
T123655-100mg | 100mg | In stock | $99.90 | |
T123655-250mg | 250mg | In stock | $199.90 | |
T123655-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $479.90 | |
T123655-5g | 5g | In stock | $1,499.90 |
Antiproliferative and antioxidant agent
Synonyms | NSC 618905 | Tangeritin | Pentamethoxyflavone | NSC 53909 | 4',5,6,7,8-Pentamethoxyflavone | 5,6,7,8,4'-Pentamethoxyflavone | Ponkanetin | 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication. and to inhibit cell prolifera |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one |
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INCHI | InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3 |
InChi Key | ULSUXBXHSYSGDT-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC |
Isomeric SMILES | COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC |
WGK Germany | 3 |
RTECS | DJ3102725 |
PubChem CID | 68077 |
Molecular Weight | 372.37 |
Beilstein | 351695 |
Reaxy-Rn | 351695 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2411495 | Certificate of Analysis | Nov 02, 2024 | T123655 |
K2411488 | Certificate of Analysis | Nov 02, 2024 | T123655 |
K2411487 | Certificate of Analysis | Nov 02, 2024 | T123655 |
K2411486 | Certificate of Analysis | Nov 02, 2024 | T123655 |
K2411479 | Certificate of Analysis | Nov 02, 2024 | T123655 |
I2419581 | Certificate of Analysis | Sep 05, 2024 | T123655 |
I2419582 | Certificate of Analysis | Sep 05, 2024 | T123655 |
I2419583 | Certificate of Analysis | Sep 05, 2024 | T123655 |
I2419584 | Certificate of Analysis | Sep 05, 2024 | T123655 |
I1820189 | Certificate of Analysis | Jul 20, 2022 | T123655 |
I1401040 | Certificate of Analysis | Jun 20, 2022 | T123655 |
L2326059 | Certificate of Analysis | Mar 14, 2022 | T123655 |
E2225039 | Certificate of Analysis | Mar 14, 2022 | T123655 |
K2422258 | Certificate of Analysis | Mar 14, 2022 | T123655 |
G2418022 | Certificate of Analysis | Mar 14, 2022 | T123655 |
E2225216 | Certificate of Analysis | Mar 14, 2022 | T123655 |
E2225049 | Certificate of Analysis | Mar 14, 2022 | T123655 |
E2225047 | Certificate of Analysis | Mar 14, 2022 | T123655 |
E2225043 | Certificate of Analysis | Mar 14, 2022 | T123655 |
E2225040 | Certificate of Analysis | Mar 14, 2022 | T123655 |
Sensitivity | Heat Sensitive |
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Melt Point(°C) | 153.0-157.0°C |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | DJ3102725 |
Reaxy-Rn | 351695 |
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1. Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu. (2023) Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. Frontiers in Immunology, 14 (1134556). [PMID:37205094] |
2. Yajing Fang, Fuqiang Liang, Mengmeng Xia, Weiwei Cao, Siyi Pan, Ting Wu, Xiaoyun Xu. (2021) Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells. FOOD AND CHEMICAL TOXICOLOGY, 155 (112381). [PMID:34217736] |
3. Xin Huang, Junxiang Zhu, Li Wang, Huijuan Jing, Chaoyang Ma, Xingran Kou, Hongxin Wang. (2020) Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 164 (1927). [PMID:32795575] |
4. Yao Hu, Yang Qin, Chao Qiu, Xueming Xu, Zhengyu Jin, Jinpeng Wang. (2020) Ultrasound-assisted self-assembly of β-cyclodextrin/debranched starch nanoparticles as promising carriers of tangeretin. FOOD HYDROCOLLOIDS, 108 (106021). [PMID:] |
5. Xin Huang, Xingran Kou, Li Wang, Ruya Ji, Chaoyang Ma, Hongxin Wang. (2019) Effective hydroxylation of tangeretin from Citrus Peel (Chenpi) by edible acids and its improvement in antioxidant and anti-lipase activities. LWT-FOOD SCIENCE AND TECHNOLOGY, 116 (108469). [PMID:] |
6. Fuqiang Liang, Yajing Fang, Weiwei Cao, Zhuo Zhang, Siyi Pan, Xiaoyun Xu. (2018) Attenuation of tert-Butyl Hydroperoxide (t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2–ARE and MAPK Signaling Pathways. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (25): (6317–6325). [PMID:29871486] |
7. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044] |
1. Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu. (2023) Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. Frontiers in Immunology, 14 (1134556). [PMID:37205094] |
2. Yajing Fang, Fuqiang Liang, Mengmeng Xia, Weiwei Cao, Siyi Pan, Ting Wu, Xiaoyun Xu. (2021) Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells. FOOD AND CHEMICAL TOXICOLOGY, 155 (112381). [PMID:34217736] |
3. Xin Huang, Junxiang Zhu, Li Wang, Huijuan Jing, Chaoyang Ma, Xingran Kou, Hongxin Wang. (2020) Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 164 (1927). [PMID:32795575] |
4. Yao Hu, Yang Qin, Chao Qiu, Xueming Xu, Zhengyu Jin, Jinpeng Wang. (2020) Ultrasound-assisted self-assembly of β-cyclodextrin/debranched starch nanoparticles as promising carriers of tangeretin. FOOD HYDROCOLLOIDS, 108 (106021). [PMID:] |
5. Xin Huang, Xingran Kou, Li Wang, Ruya Ji, Chaoyang Ma, Hongxin Wang. (2019) Effective hydroxylation of tangeretin from Citrus Peel (Chenpi) by edible acids and its improvement in antioxidant and anti-lipase activities. LWT-FOOD SCIENCE AND TECHNOLOGY, 116 (108469). [PMID:] |
6. Fuqiang Liang, Yajing Fang, Weiwei Cao, Zhuo Zhang, Siyi Pan, Xiaoyun Xu. (2018) Attenuation of tert-Butyl Hydroperoxide (t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2–ARE and MAPK Signaling Pathways. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (25): (6317–6325). [PMID:29871486] |
7. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044] |