Tanshinone I - 97%, high purity , CAS No.568-73-0

  • ≥97%
Item Number
T118876
Grouped product items
SKUSizeAvailabilityPrice Qty
T118876-100mg
100mg
In stock
$266.90
T118876-500mg
500mg
In stock
$1,201.90

Basic Description

SynonymsTanshinone I, analytical standard | AKOS005613012 | NCGC00247624-02 | TanshinoneI | Tanshinone-I | 1,6-Dimethyl-phenanthro[1,2-b]furan-10,11-dione | 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione | 1,6-dimethylnaphtho[1,2-g]benzofuran-10,11-quinone | AS-6
Specifications & Purity≥97%
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells.
A biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKR1B1 Tclin Aldose reductase (1404 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CES2 Tchem Carboxylesterase 2 (583 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TERT Tchem Telomerase reverse transcriptase (2428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGS (1999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U373 MG (658 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGLL Tchem Monoglyceride lipase (1909 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver (3974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLC-PRF-5 (244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CGA Tbio Glycoprotein hormones alpha chain (29278 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EZH2 Tclin EZH2/SUZ12/EED complex (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hep 3B2 (2332 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Papain (844 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS coronavirus 3C-like proteinase (333 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus (3973 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus sp. 'group A' (3417 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Protease (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGR Thioredoxin glutathione reductase (28579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ska Streptokinase A (5805 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
INCHI InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChi Key AIGAZQPHXLWMOJ-UHFFFAOYSA-N
Canonical SMILES CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C
Isomeric SMILES CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C
WGK Germany 3
PubChem CID 114917
Molecular Weight 276.29

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
I2201674Certificate of AnalysisSep 06, 2022 T118876
I2201677Certificate of AnalysisSep 06, 2022 T118876
F2115200Certificate of AnalysisJun 07, 2022 T118876
F2115201Certificate of AnalysisJun 07, 2022 T118876

Chemical and Physical Properties

Refractive Index1.68
Boil Point(°C)474-522 °C
Melt Point(°C)233-234℃

Safety and Hazards(GHS)

Hazard Statements

H413:May cause long lasting harmful effects to aquatic life

WGK Germany 3

Related Documents

Citations of This Product

1. Sun Kai, Xue Yuman, Zhang Xin, Li Xiaodong, Zhao Jun, Xu Xilin, Zhang Xiaofeng, Yang Fubiao.  (2023)  Tanshinone I alleviates steroid-induced osteonecrosis of femoral heads and promotes angiogenesis: in vivo and in vitro studies.  Journal of Orthopaedic Surgery and Research,  18  (1): (1-15).  [PMID:37391758] [10.1186/s13018-023-03934-y]
2. Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang.  (2022)  Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway.  PHYTOMEDICINE,  106  (154439).  [PMID:36108374] [10.1016/j.phymed.2022.154439]
3. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei.  (2022)  Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS.  Frontiers in Chemistry,  10    [PMID:35910733] [10.3389/fchem.2022.964744]
4. Zhou Wei, Shi Min, Deng Changping, Lu Sunjie, Huang Fenfen, Wang Yao, Kai Guoyin.  (2021)  The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza.  Horticulture Research,    [PMID:33384411] [10.1038/s41438-020-00443-5]
5. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai.  (2019)  Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots.  PLANT SCIENCE,  284  (1).  [PMID:31084862] [10.1016/j.plantsci.2019.03.007]
6. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang.  (2017)  Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs).  PHARMACEUTICAL BIOLOGY,      [PMID:28466663] [10.3109/13880209.2015.1045621]
7. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen.  (2016)  Ball mill assisted rapid mechanochemical extraction method for natural products from plants.  JOURNAL OF CHROMATOGRAPHY A,  1449  (8).  [PMID:27157426] [10.1016/j.chroma.2016.04.044]
8. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin.  (2016)  Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins.  Scientific Reports,  (1): (1-11).  [PMID:26875847] [10.1038/srep20919]
9. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai.  (2016)  Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  64  (12): (2523–2530).  [PMID:26753746] [10.1021/acs.jafc.5b04697]
10. Chenchen Zhang, Shan Jiang, Kun Li, Mei Wang, Rongrong Zhu, Xiaoyu Sun, Qingxiu Wang, ShiLong Wang.  (2015)  The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  150  (181).  [PMID:26046496] [10.1016/j.saa.2015.05.062]

References

1. Sun Kai, Xue Yuman, Zhang Xin, Li Xiaodong, Zhao Jun, Xu Xilin, Zhang Xiaofeng, Yang Fubiao.  (2023)  Tanshinone I alleviates steroid-induced osteonecrosis of femoral heads and promotes angiogenesis: in vivo and in vitro studies.  Journal of Orthopaedic Surgery and Research,  18  (1): (1-15).  [PMID:37391758] [10.1186/s13018-023-03934-y]
2. Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang.  (2022)  Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway.  PHYTOMEDICINE,  106  (154439).  [PMID:36108374] [10.1016/j.phymed.2022.154439]
3. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei.  (2022)  Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS.  Frontiers in Chemistry,  10    [PMID:35910733] [10.3389/fchem.2022.964744]
4. Zhou Wei, Shi Min, Deng Changping, Lu Sunjie, Huang Fenfen, Wang Yao, Kai Guoyin.  (2021)  The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza.  Horticulture Research,    [PMID:33384411] [10.1038/s41438-020-00443-5]
5. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai.  (2019)  Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots.  PLANT SCIENCE,  284  (1).  [PMID:31084862] [10.1016/j.plantsci.2019.03.007]
6. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang.  (2017)  Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs).  PHARMACEUTICAL BIOLOGY,      [PMID:28466663] [10.3109/13880209.2015.1045621]
7. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen.  (2016)  Ball mill assisted rapid mechanochemical extraction method for natural products from plants.  JOURNAL OF CHROMATOGRAPHY A,  1449  (8).  [PMID:27157426] [10.1016/j.chroma.2016.04.044]
8. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin.  (2016)  Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins.  Scientific Reports,  (1): (1-11).  [PMID:26875847] [10.1038/srep20919]
9. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai.  (2016)  Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  64  (12): (2523–2530).  [PMID:26753746] [10.1021/acs.jafc.5b04697]
10. Chenchen Zhang, Shan Jiang, Kun Li, Mei Wang, Rongrong Zhu, Xiaoyu Sun, Qingxiu Wang, ShiLong Wang.  (2015)  The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  150  (181).  [PMID:26046496] [10.1016/j.saa.2015.05.062]

Solution Calculators