Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T109795-50mg | 50mg | In stock | $216.90 | |
T109795-100mg | 100mg | In stock | $390.90 | |
T109795-250mg | 250mg | In stock | $878.90 | |
T109795-1g | 1g | In stock | $3,163.90 | |
T109795-5g | 5g | In stock | $14,237.90 |
Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
Synonyms | CHEBI:108595 | KBio2_000317 | NCGC00095709-04 | Phenanthro[1,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl- | MLS006011834 | TANSHINONE IIA (CONSTITUENT OF CHINESE SALVIA) | BCP28199 | 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Major tanshinone isolated fromSalvia miltiorrhiza. Inhibits NF-κB and AP-1 DNA binding. Exhibits cytotoxic activity in a number of different cancer cells. Inhibitsβ-amyloid aggregation and protects PC12 cells fromβ-amyloid-induced apoptosis. Displays anti |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Product Description | Tanshinone IIA (Dan Shen ketone), vasoactive cardioprotective drug, is used in a wide variety of studies to asses is potential therapeutic value and mechanisms of action which include inhibiting LDL oxidation, monocyte adhesion to endothelium, smooth muscle cell migration and proliferation, macrophage cholesterol accumulation, proinflammatory cytokine expression and platelet aggregation. |
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IUPAC Name | 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione |
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INCHI | InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3 |
InChi Key | HYXITZLLTYIPOF-UHFFFAOYSA-N |
Canonical SMILES | CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C |
Isomeric SMILES | CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C |
WGK Germany | 3 |
RTECS | SF8282695 |
PubChem CID | 164676 |
Molecular Weight | 294.34 |
Reaxy-Rn | 288781 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2405524 | Certificate of Analysis | Mar 15, 2024 | T109795 |
F2405527 | Certificate of Analysis | Mar 15, 2024 | T109795 |
J2314499 | Certificate of Analysis | Oct 20, 2023 | T109795 |
J2314498 | Certificate of Analysis | Oct 20, 2023 | T109795 |
J2314497 | Certificate of Analysis | Oct 20, 2023 | T109795 |
B2418223 | Certificate of Analysis | Oct 20, 2023 | T109795 |
G2317032 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317069 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317042 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317040 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317039 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317035 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317029 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317028 | Certificate of Analysis | Jul 25, 2023 | T109795 |
G2317021 | Certificate of Analysis | Jul 25, 2023 | T109795 |
H2120502 | Certificate of Analysis | Aug 24, 2021 | T109795 |
F2210122 | Certificate of Analysis | Aug 24, 2021 | T109795 |
F2210121 | Certificate of Analysis | Aug 24, 2021 | T109795 |
F2210120 | Certificate of Analysis | Aug 24, 2021 | T109795 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 1.47, Max Conc. mM: 5 with gentle warming |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 209°C-210°C |
WGK Germany | 3 |
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RTECS | SF8282695 |
Reaxy-Rn | 288781 |
1. Jiaqi Zhang, Haole Qi, Mingxia Wang, Yongqin Wei, Hao Liang. (2023) Enzymatically hydrolyzed sodium caseinate nanoparticles efficiently enhancing the solubility, stability, and antioxidant and anti-biofilm activities of hydrophobic Tanshinone IIA. Journal of Materials Chemistry B, 11 (11): (2440-2454). [PMID:36810656] [10.1039/D2TB02263J] |
2. Ling Yu, Yubin Liang, Lei Gao, Peipei Chen, Zhiqiang Yu, Minzhou Zhang, Aleksander Hinek, Shuai Mao. (2023) Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone IIA@ Reactive Oxygen Species-Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel. Energy & Environmental Materials, (e12555). [PMID:] [10.1002/eem2.12555] |
3. Yingru Zhang, Yiyang Zhao, Jingwen Liu, Chunpu Li, Ying Feng, Shasha Jiang, Xiaoting Sun, Xueqing Hu, Yan Wang. (2022) Transgelin-2 Involves in the Apoptosis of Colorectal Cancer Cells Induced by Tanshinone-IIA. Analytical Cellular Pathology, 2022 (9358583). [PMID:36204303] [10.1155/2022/9358583] |
4. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, 73 (182). [PMID:35934177] [10.1016/j.ymben.2022.08.002] |
5. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
6. Meixuan Liu, Sha Liu, Xiaosu Zhu, Yiying Sun, Linyu Su, Hairong Yu, Deshuai Liu, Ying Li, Yuan Du, Rongxia Liu, Kaoxiang Sun. (2022) Tanshinone IIA-Loaded Micelles Functionalized with Rosmarinic Acid: A Novel Synergistic Anti-Inflammatory Strategy for Treatment of Atherosclerosis. JOURNAL OF PHARMACEUTICAL SCIENCES, 111 (2827). [PMID:35580692] [10.1016/j.xphs.2022.05.007] |
7. Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen. (2021) Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling. Annals of Hepatology, 20 (100259). [PMID:32980439] [10.1016/j.aohep.2020.07.013] |
8. Xiaolong Hao, Zhongqiang Pu, Gang Cao, Dawei You, Yang Zhou, Changping Deng, Min Shi, Shivraj Hariram Nile, Yao Wang, Wei Zhou, Guoyin Kai. (2020) Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots. Journal of Advanced Research, 23 (1). [PMID:32071787] [10.1016/j.jare.2020.01.012] |
9. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, 284 (1). [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
10. Jian Fang, Qiuyan Chen, Baozhu He, Jiaxuan Cai, Yawen Yao, Yi Cai, Suowen Xu, Kannan R.R. Rengasamy, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian, Tiansheng Cao. (2018) Tanshinone IIA attenuates TNF-α induced PTX3 expression and monocyte adhesion to endothelial cells through the p38/NF-κB pathway. FOOD AND CHEMICAL TOXICOLOGY, 121 (622). [PMID:30268796] [10.1016/j.fct.2018.09.063] |
11. Chong Zhong, Yong-Fa Zhang, Jun-Hai Huang, Zi-Yu Wang, Qiu-Yuan Chen, Li-Tian Su, Zhen-Tao Liu, Cheng-Ming Xiong, Zhi Tao, Rong-Ping Guo. (2017) The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3/Smad7 cascade. American Journal of Translational Research, 9 (6): ( 2694–2711). [PMID:28670362] [PMID:28670362] |
12. Zhu Yingchun, Tang Qiqiang, Wang Guopin, Han Ruodong. (2017) Tanshinone IIA Protects Hippocampal Neuronal Cells from Reactive Oxygen Species Through Changes in Autophagy and Activation of Phosphatidylinositol 3-Kinase, Protein Kinas B, and Mechanistic Target of Rapamycin Pathways. CURRENT NEUROVASCULAR RESEARCH, 14 (2): (132-140). [PMID:28260507] [10.2174/1567202614666170306105315] |
13. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
14. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, 1449 (8). [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
15. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
16. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64 (12): (2523–2530). [PMID:26753746] [10.1021/acs.jafc.5b04697] |
17. Chen Minggang, Liu Yumei, Yi Dan, Wei Liuping, Li Yumei, Zhang Li. (2014) Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis in Vitro by Inhibiting the JAK2/STAT3 Signaling Pathway. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 (4): (1130-1138). [PMID:24733040] [10.1159/000358682] |
1. Jiaqi Zhang, Haole Qi, Mingxia Wang, Yongqin Wei, Hao Liang. (2023) Enzymatically hydrolyzed sodium caseinate nanoparticles efficiently enhancing the solubility, stability, and antioxidant and anti-biofilm activities of hydrophobic Tanshinone IIA. Journal of Materials Chemistry B, 11 (11): (2440-2454). [PMID:36810656] [10.1039/D2TB02263J] |
2. Ling Yu, Yubin Liang, Lei Gao, Peipei Chen, Zhiqiang Yu, Minzhou Zhang, Aleksander Hinek, Shuai Mao. (2023) Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone IIA@ Reactive Oxygen Species-Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel. Energy & Environmental Materials, (e12555). [PMID:] [10.1002/eem2.12555] |
3. Yingru Zhang, Yiyang Zhao, Jingwen Liu, Chunpu Li, Ying Feng, Shasha Jiang, Xiaoting Sun, Xueqing Hu, Yan Wang. (2022) Transgelin-2 Involves in the Apoptosis of Colorectal Cancer Cells Induced by Tanshinone-IIA. Analytical Cellular Pathology, 2022 (9358583). [PMID:36204303] [10.1155/2022/9358583] |
4. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, 73 (182). [PMID:35934177] [10.1016/j.ymben.2022.08.002] |
5. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
6. Meixuan Liu, Sha Liu, Xiaosu Zhu, Yiying Sun, Linyu Su, Hairong Yu, Deshuai Liu, Ying Li, Yuan Du, Rongxia Liu, Kaoxiang Sun. (2022) Tanshinone IIA-Loaded Micelles Functionalized with Rosmarinic Acid: A Novel Synergistic Anti-Inflammatory Strategy for Treatment of Atherosclerosis. JOURNAL OF PHARMACEUTICAL SCIENCES, 111 (2827). [PMID:35580692] [10.1016/j.xphs.2022.05.007] |
7. Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen. (2021) Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling. Annals of Hepatology, 20 (100259). [PMID:32980439] [10.1016/j.aohep.2020.07.013] |
8. Xiaolong Hao, Zhongqiang Pu, Gang Cao, Dawei You, Yang Zhou, Changping Deng, Min Shi, Shivraj Hariram Nile, Yao Wang, Wei Zhou, Guoyin Kai. (2020) Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots. Journal of Advanced Research, 23 (1). [PMID:32071787] [10.1016/j.jare.2020.01.012] |
9. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, 284 (1). [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
10. Jian Fang, Qiuyan Chen, Baozhu He, Jiaxuan Cai, Yawen Yao, Yi Cai, Suowen Xu, Kannan R.R. Rengasamy, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian, Tiansheng Cao. (2018) Tanshinone IIA attenuates TNF-α induced PTX3 expression and monocyte adhesion to endothelial cells through the p38/NF-κB pathway. FOOD AND CHEMICAL TOXICOLOGY, 121 (622). [PMID:30268796] [10.1016/j.fct.2018.09.063] |
11. Chong Zhong, Yong-Fa Zhang, Jun-Hai Huang, Zi-Yu Wang, Qiu-Yuan Chen, Li-Tian Su, Zhen-Tao Liu, Cheng-Ming Xiong, Zhi Tao, Rong-Ping Guo. (2017) The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3/Smad7 cascade. American Journal of Translational Research, 9 (6): ( 2694–2711). [PMID:28670362] [PMID:28670362] |
12. Zhu Yingchun, Tang Qiqiang, Wang Guopin, Han Ruodong. (2017) Tanshinone IIA Protects Hippocampal Neuronal Cells from Reactive Oxygen Species Through Changes in Autophagy and Activation of Phosphatidylinositol 3-Kinase, Protein Kinas B, and Mechanistic Target of Rapamycin Pathways. CURRENT NEUROVASCULAR RESEARCH, 14 (2): (132-140). [PMID:28260507] [10.2174/1567202614666170306105315] |
13. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
14. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, 1449 (8). [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
15. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
16. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64 (12): (2523–2530). [PMID:26753746] [10.1021/acs.jafc.5b04697] |
17. Chen Minggang, Liu Yumei, Yi Dan, Wei Liuping, Li Yumei, Zhang Li. (2014) Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis in Vitro by Inhibiting the JAK2/STAT3 Signaling Pathway. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 (4): (1130-1138). [PMID:24733040] [10.1159/000358682] |