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Taranabant - ≥98%, high purity , Cannabinoid CB1 receptor inverse agonist, CAS No.701977-09-5, Cannabinoid CB1 receptor inverse agonist

Moligand™
≥98%

CAS#: 701977-09-5
Formula: C₂₇H₂₅ClF₃N₃O₂
Molecular Weight: 515.97
PubChem CID: 11226090

Item Number

T126945

Grouped product items
SKU	Size	Availability	Price	Qty
T126945-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
T126945-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$189.90

View related series

CB1 receptor Antagonist CB2 receptor Agonist

Basic Description

Synonyms	Taranabant\|701977-09-5\|MK-0364\|MK 0364\|MK0364\|Taranabant (MK-0364)\|Tranabant (MK-0364)\|MK-0634\|CHEMBL220360\|X9U622S114\|N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide( MK 0364)\|1
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Taranabant is a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist （CB1 Antagonist）for the Treatment of Obesity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST, INVERSE AGONIST
Mechanism of action	Cannabinoid CB1 receptor inverse agonist

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 1 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 23 Activities

Discover Target: CNR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR2 Tchem Cannabinoid receptor 2 1 Activities

Discover Target: CNR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 1 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxypropanamide
INCHI	InChI=1S/C27H25ClF3N3O2/c1-17(34-25(35)26(2,3)36-24-12-9-21(16-33-24)27(29,30)31)23(14-18-7-10-22(28)11-8-18)20-6-4-5-19(13-20)15-32/h4-13,16-17,23H,14H2,1-3H3,(H,34,35)/t17-,23+/m0/s1
InChi Key	QLYKJCMUNUWAGO-GAJHUEQPSA-N
Canonical SMILES	CC(C(CC1=CC=C(C=C1)Cl)C2=CC=CC(=C2)C#N)NC(=O)C(C)(C)OC3=NC=C(C=C3)C(F)(F)F
Isomeric SMILES	C[C@@H]([C@@H](CC1=CC=C(C=C1)Cl)C2=CC=CC(=C2)C#N)NC(=O)C(C)(C)OC3=NC=C(C=C3)C(F)(F)F
PubChem CID	11226090
Molecular Weight	515.97

ChEMBL Ligand

PubChem CID

BindingDB Ligand

CAS Registry No.

RCSB PDB Ligand

GPCRdb Ligand

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09
Signal	Danger
Hazard Statements	H400:Very toxic to aquatic life H372:Causes damage to organs through prolonged or repeated exposure
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P319:Get medical help if you feel unwell.

References

1. Foloppe N, Benwell K, Brooks TD, Kennett G, Knight AR, Misra A, Monck NJ. (2009) Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.. Bioorg Med Chem Lett, 19 (15): (4183-90). [PMID:19520572]
2. Lin LS, Ha S, Ball RG, Tsou NN, Castonguay LA, Doss GA, Fong TM, Shen CP, Xiao JC, Goulet MT et al.. (2008) Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.. J Med Chem, 51 (7): (2108-14). [PMID:18333607]
3. Addy C, Wright H, Van Laere K, Gantz I, Erondu N, Musser BJ, Lu K, Yuan J, Sanabria-Bohórquez SM, Stoch A et al.. (2008) The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.. Cell Metab, 7 (1): (68-78). [PMID:18177726]

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