Taraxerol - ≥98.0%, high purity , CAS No.127-22-0

  • ≥98%
Item Number
T651169
Grouped product items
SKUSizeAvailabilityPrice Qty
T651169-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$100.90
T651169-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$250.90
T651169-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$420.90

Terpenoids Triterpenes

View related series
NF-κB Terpenoids Triterpenes

Basic Description

Synonymsalnulin | TARAXEROL [MI] | DTXSID001026552 | 27-Norolean-14-en-3-ol, 13-methyl-, (3beta,13alpha)- | skimmiol | BDBM50242128 | CS-0022748 | ISOOLEAN-14-EN-3beta-OL | AKOS032962064 | ISOOLEAN-14-EN-3.BETA.-OL | SCHEMBL569463 | NIOSH/AM5850000 | (3beta)-D-fr
Specifications & Purity≥98%
Biochemical and Physiological MechanismsTaraxerol is isolated from Taraxacum mongolicum , and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis.
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

Taraxerol is isolated from Taraxacum mongolicum , and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis

In Vitro

Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: apoptosis

Associated Targets(Human)

Calu-1 (518 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Raji (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WISH (126 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L6 (7924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (3S,4aR,6aR,6aS,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-ol
INCHI InChI=1S/C30H50O/c1-25(2)17-18-27(5)13-9-21-29(7)14-10-20-26(3,4)24(31)12-16-28(20,6)22(29)11-15-30(21,8)23(27)19-25/h9,20,22-24,31H,10-19H2,1-8H3/t20-,22+,23+,24-,27-,28-,29-,30+/m0/s1
InChi Key GGGUGZHBAOMSFJ-GADYQYKKSA-N
Canonical SMILES CC1(CCC2(CC=C3C4(CCC5C(C(CCC5(C4CCC3(C2C1)C)C)O)(C)C)C)C)C
Isomeric SMILES C[C@]12CCC(C[C@H]1[C@@]3(CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4(C3=CC2)C)(C)C)O)C)C)(C)C
Alternate CAS 127-22-0
PubChem CID 92097
MeSH Entry Terms 3beta-taraxerol;D-friedoolean-14-en-3 beta-ol;taraxerol
Molecular Weight 426.72

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityTHF : 10 mg/mL (23.43 mM; Need ultrasonic) DMSO : <1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble)

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