| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab175667-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
| Ab175667-1mg | 1mg | In stock | $259.90 | |
| Ab175667-5mg | 5mg | In stock | $749.90 | |
| Ab175667-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,189.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Tarextumab (anti-NOTCH3) - Primary antibody, specific to NOTCH3, >95%, high purity, Human IgG2 |
|---|---|
| Synonyms | CADASIL antibody | CASIL antibody | NOTC3_HUMAN antibody | Notch 3 antibody | Notch 3 intracellular domain antibody | Notch homolog 3 antibody | Notch3 antibody | CADASIL | CASILneurogenic locus notch homolog protein 3 | Notch (Drosophila) homolog 3 | not |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Host species | Human |
| Specificity | NOTCH3 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of notch receptor 2;Antibody of notch receptor 3 |
| Product Description | Tarextumab (anti-NOTCH3) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab (anti-NOTCH3) shows anti-tumor activity. |
| Isotype | Human IgG2 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.0 kDa (Light Chain) & 48.6 kDa (Heavy Chain), under reducing conditions; 162.7 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1359940-55-8 |
Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tarextumab (anti-NOTCH3) (Ab175667) - SEC
The purity of Tarextumab (anti-NOTCH3) (Ab175667) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IMGT/mAb-DB | 467 |
|---|---|
| Wikipedia | Tarextumab |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1202013 | Certificate of Analysis | Dec 13, 2023 | Ab175667 |
| ZJ23F1202014 | Certificate of Analysis | Dec 13, 2023 | Ab175667 |
| 1. Shan W, Balog A, Quesnelle C, Gill P, Han WC, Norris D, Mandal S, Thiruvenkadam R, Gona KB, Thiyagarajan K, Kandula S, McGlinchey K, Menard K, Wen ML, Rose A, White R, Guarino V, Shen DR, Cvijic ME, Ranasinghe A, Dai J, Zhang Y, Wu DR, Mathur A, Rampulla R, Trainor G, Hunt JT, Vite GD, Westhouse R, Lee FY, Gavai AV.. (2015) BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.. Bioorg Med Chem Lett, 25 (9): (1905-1909). [PMID:25857941] [10.1016/j.bmcl.2015.03.038] |
| 2. Joutel, A A and 18 more authors.. (1996) Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.. Nature, (24): [PMID:8878478] |
| 3. Joutel, A A and 11 more authors.. (1997) Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients.. Lancet (London, England), (22): [PMID:9388399] |
| 4. Gray, G E GE and 9 more authors.. (1999) Human ligands of the Notch receptor.. The American journal of pathology, [PMID:10079256] |
| 5. Dichgans, M M and 10 more authors.. (1999) Quantitative MRI in CADASIL: correlation with disability and cognitive performance.. Neurology, (22): [PMID:10227618] |
| 6. Oberstein, S A SA and 7 more authors.. (1999) Diagnostic Notch3 sequence analysis in CADASIL: three new mutations in Dutch patients. Dutch CADASIL Research Group.. Neurology, (10): [PMID:10371548] |
| 7. Joutel, A A and 9 more authors.. (2000) Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL.. Neurology, (9): [PMID:10802807] |
| 8. Dichgans, M M, Ludwig, H H, Müller-Höcker, J J, Messerschmidt, A A and Gasser, T T.. (2000) Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains.. European journal of human genetics : EJHG, [PMID:10854111] |
| 9. Grigg, R R and 5 more authors.. (2000) Identification of a novel mutation C144F in the Notch3 gene in an Australian CADASIL pedigree.. Human mutation, [PMID:11058919] |
| 10. Wu, L L and 5 more authors.. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.. Nature genetics, [PMID:11101851] |
| 11. Escary, J L JL and 5 more authors.. (2000) Evaluation of DHPLC analysis in mutational scanning of Notch3, a gene with a high G-C content.. Human mutation, [PMID:11102981] |
| 12. Oliveri, R L RL and 13 more authors.. (2001) A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: genetic and magnetic resonance spectroscopic findings.. Archives of neurology, [PMID:11559313] |
| 13. Joutel, A A and 12 more authors.. (2001) Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis.. Lancet (London, England), (15): [PMID:11755616] |
| 14. Feuerhake, F F and 6 more authors.. (2002) Reversible coma with raised intracranial pressure: an unusual clinical manifestation of CADASIL.. Acta neuropathologica, [PMID:11810186] |
| 15. Arboleda-Velasquez, J F JF and 16 more authors.. (2002) C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke.. Neurology, (23): [PMID:12136071] |
| 16. Kalimo, Hannu H, Ruchoux, Marie-Magdaleine MM, Viitanen, Matti M and Kalaria, Raj N RN.. (2002) CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia.. Brain pathology (Zurich, Switzerland), [PMID:12146805] |
| 17. Wu, Lizi L, Sun, Tao T, Kobayashi, Karla K, Gao, Ping P and Griffin, James D JD.. (2002) Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.. Molecular and cellular biology, [PMID:12370315] |
| 18. Moon, So-Young SY and 7 more authors.. (2003) A novel mutation (C67Y)in the NOTCH3 gene in a Korean CADASIL patient.. Journal of Korean medical science, [PMID:12589106] |
| 19. Santa, Yo Y and 6 more authors.. (2003) Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis.. Journal of the neurological sciences, (15): [PMID:12810003] |
| 20. Singhal, Sumeet S, Bevan, Steve S, Barrick, Tom T, Rich, Philip P and Markus, Hugh S HS.. (2004) The influence of genetic and cardiovascular risk factors on the CADASIL phenotype.. Brain : a journal of neurology, [PMID:15229130] |
| 21. Rojas-Marcos, I I and 6 more authors.. (2004) Gene symbol: NOTCH3. Disease: CADASIL.. Human genetics, [PMID:15300988] |
| 22. Peters, Nils N and 5 more authors.. (2004) CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk.. Experimental cell research, (1): [PMID:15350543] |
| 23. Opherk, Christian C, Peters, Nils N, Herzog, Jürgen J, Luedtke, Rainer R and Dichgans, Martin M.. (2004) Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients.. Brain : a journal of neurology, [PMID:15364702] |
| 24. Mykkänen, Kati K and 10 more authors.. (2004) Detection of the founder effect in Finnish CADASIL families.. European journal of human genetics : EJHG, [PMID:15378071] |
| 25. Soong, B W BW, Lee, Yi-Chung YC and Lu, Yi-Chun YC.. (2005) Gene symbol: NOTCH3. Disease: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.. Human genetics, [PMID:15818833] |
| 26. Peters, Nils N and 5 more authors.. (2005) Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies.. Archives of neurology, [PMID:16009764] |
| 27. Zhang, Yanmei Y, Jia, Lijun L, Lee, Soo Jung SJ and Wang, Michael M MM.. (2007) Conserved signal peptide of Notch3 inhibits interaction with proteasome.. Biochemical and biophysical research communications, (30): [PMID:17292860] |
| 28. Coleman, Mathew L ML and 12 more authors.. (2007) Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.. The Journal of biological chemistry, (17): [PMID:17573339] |
| 29. Fouillade, Charles C and 8 more authors.. (2008) Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain.. Human mutation, [PMID:18273901] |
| 30. Zheng, Xiaofeng X and 18 more authors.. (2008) Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.. Proceedings of the National Academy of Sciences of the United States of America, (4): [PMID:18299578] |
| 31. Martignetti, John A JA and 27 more authors.. (2013) Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis.. American journal of human genetics, (6): [PMID:23731542] |
| 32. Rutten, Julie W JW and 11 more authors.. (2013) Hypomorphic NOTCH3 alleles do not cause CADASIL in humans.. Human mutation, [PMID:24000151] |
| 33. Guo, Ailan and 15 more authors.. (2014) Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.. Molecular & cellular proteomics : MCP, [PMID:24129315] |
| 34. Gripp, Karen W KW and 12 more authors.. (2015) Truncating mutations in the last exon of NOTCH3 cause lateral meningocele syndrome.. American journal of medical genetics. Part A, [PMID:25394726] |
