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PLG

DescriptionPlasminogen

Gene and Protein Information

Gene ID5340
Uniprot Accession IDs Q15146 Q5TEH4 Q6PA00
Ensembl ID ENSP00000308938
FamilyBelongs to the peptidase S1 family. Plasminogen subfamily.
Sequence
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463117PLGplasminogen9598VGNC:11165OMA, EggNOG
Macaque703891PLGplasminogen9544Inparanoid, OMA, EggNOG
Mouse18815Plgplasminogen10090MGI:97620Inparanoid, OMA, EggNOG
Rat85253Plgplasminogen10116RGD:619893Inparanoid, OMA, EggNOG
Dog403602PLGplasminogen9615OMA, EggNOG
Horse100050531PLGplasminogen9796OMA, EggNOG
Cow280897PLGplasminogen9913Inparanoid, OMA, EggNOG
Pig733660PLGplasminogen9823Inparanoid, OMA, EggNOG
Opossum100028030PLGplasminogen13616OMA, EggNOG
Chicken421580PLGplasminogen9031CGNC:51506Inparanoid, OMA, EggNOG
Anole lizard100554661plgplasminogen28377OMA, EggNOG
Zebrafish322691plgplasminogen7955ZDB-GENE-030131-1411Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    serine protease    /    Plasminogen
protein    /    protease    /    Plasminogen
protein    /    hydrolase    /    Plasminogen
DTO Classes
protein    /    Enzyme    /    Protease    /    Serine protease    /    Plasminogen

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

    1. 6-aminocaproic acidTetrahydrouridine

      RETTclinpeptidase

      IC50 p: 4.40

    2. tranexamic acidTetrahydrouridine

      RETTclinpeptidase

      IC50 p: 3.59

    3. bis-triazole derivative 10Tetrahydrouridine

      RETTclinpeptidase

      Ki p: 9.10

    4. Peptide boronateTetrahydrouridine

      RETTclinpeptidase

      Ki p: 11.00

    5. 2'-(4-Carbamimidoylphenylcarbamoyl)-4-(isobutylcarbamoyl)-4'-(thiophen-3-yl)biphenyl-2-carboxylic acidTetrahydrouridine

      RETTclinpeptidase

      IC50 p: 10.46

    6. NATetrahydrouridine

      RETTclinpeptidase

      Ki p: 10.39

    7. NATetrahydrouridine

      RETTclinpeptidase

      Ki p: 10.29

    8. 2'-(4-Carbamimidoylphenylcarbamoyl)-4'-(4-(hydroxymethyl)thiophen-3-yl)-4-(isobutylcarbamoyl)biphenyl-2-carboxylic acidTetrahydrouridine

      RETTclinpeptidase

      IC50 p: 10.22

    9. 2'-(4-Carbamimidoylphenylcarbamoyl)-4-(isobutylcarbamoyl)-4'-(prop-1-en-2-yl)biphenyl-2-carboxylic acidTetrahydrouridine

      RETTclinpeptidase

      IC50 p: 10.15

    10. NATetrahydrouridine

      RETTclinpeptidase

      Ki p: 10.15

    Associated Diseases

    NameDirect Associated TargetsDisease TypeMondoid
    Plasminogen deficiency0UniProt Disease
    Hypoplasminogenemia1MonarchMONDO:0009009
    Ligneous conjunctivitis1MonarchMONDO:0019946
    nephrosclerosis331Expression AtlasMONDO:0006044
    pancreatic ductal adenocarcinoma liver metastasis3122Expression AtlasMONDO:0005184
    Acute Kidney Injury86CTDMONDO:0002492
    Chemical and Drug Induced Liver Injury338CTDMONDO:0005359
    Drug-Related Side Effects and Adverse Reactions0CTD
    Hypertension194CTDMONDO:0005044
    Leukocyte Disorders2CTDMONDO:0004805

    Pathway

    Data SourceNameExplore more targetsExplore in Source