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1.17.4.1 Ribonucleoside-diphosphate reductases
TAS1553 , CAS No.T614336, Inhibitor of ribonucleotide reductase catalytic subunit M1

TAS1553 , CAS No.T614336, Inhibitor of ribonucleotide reductase catalytic subunit M1

Item Number

T614336

Grouped product items
SKU	Size	Availability	Price	Qty
T614336-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
T614336-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	TAS-1553
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ribonucleotide reductase catalytic subunit M1

RRM1 Tclin Ribonucleoside-diphosphate reductase large subunit (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	5-chloro-2-[[(1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(2-oxo-3H-1,3,4-oxadiazol-5-yl)propyl]sulfamoyl]benzamide
INCHI	InChI=1S/C20H20ClFN4O5S/c1-9-4-6-14(22)16(10(9)2)11(3)17(19-24-25-20(28)31-19)26-32(29,30)15-7-5-12(21)8-13(15)18(23)27/h4-8,11,17,26H,1-3H3,(H2,23,27)(H,25,28)/t11-,17+/m1/s1
InChi Key	DUYRWEBTZNUILI-DIFFPNOSSA-N
Canonical SMILES	C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)cc1C(=O)N)c1n[nH]c(=O)o1)c1c(C)c(C)ccc1F
PubChem CID	132203319

PubChem CID	132203319
BindingDB Ligand	477269

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1. Ueno H, Hoshino T, Yano W, Tsukioka S, Suzuki T, Hara S, Ogino Y, Chong KT, Suzuki T, Tsuji S et al.. (2022) TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress.. Commun Biol, 5 (1): (571). [PMID:35681099] [10.1021/op500134e]

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