Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
Product Properties
ALogP
3.6
Associated Targets
ENPP2Tchem Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 0 Activities
1.Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. (2013) The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice.. Gastroenterology, 144 (5):(989-1000.e6). [PMID:23336977]
2.Wang W, Zhao J, Gui W, Sun D, Dai H, Xiao L, Chu H, Du F, Zhu Q, Schnabl B et al.. (2018) Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease.. Br J Pharmacol, 175 (3):(469-484). [PMID:29139555]
3.Paganoni S, Macklin EA, Hendrix S, Berry JD, Elliott MA, Maiser S, Karam C, Caress JB, Owegi MA, Quick A et al.. (2020) Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.. N Engl J Med, 383 (10):(919-930). [PMID:32877582]
4.Zangerolamo L, Vettorazzi JF, Rosa LRO, Carneiro EM, Barbosa HCL. (2021) The bile acid TUDCA and neurodegenerative disorders: An overview.. Life Sci, 272 (3):(119252). [PMID:33636170]
5.Paganoni S, Hendrix S, Dickson SP, Knowlton N, Macklin EA, Berry JD, Elliott MA, Maiser S, Karam C, Caress JB et al.. (2021) Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.. Muscle Nerve, 63 (1):(31-39). [PMID:33063909]
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