Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T125016-10mg | 10mg | In stock | $73.90 | |
T125016-50mg | 50mg | In stock | $221.90 | |
T125016-250mg | 250mg | In stock | $999.90 | |
T125016-1g | 1g | In stock | $3,596.90 | |
T125016-5g | 5g | In stock | $16,183.90 |
Selective, cell-permeable casein kinase-2 (CK2) inhibitor
Synonyms | HMS3229D01 | J-010940 | TBB;1H-Benzotriazole,4,5,6,7-tetrabromo- | STO170 | 4,5,6,7-Tetrabromo-1H-benzo[d][1,2,3]triazole | HMS3413A16 | TBB;TBBT | FT-0674939 | HMS2043P01 | HMS3677A16 | 1H-Benzoriazole, 4,5,6,7-tetrahydro- | 4,5,6,7-tetrabromobenzotriazo |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | TBB is a cell-permeable benzotriazolo compound that acts as a highly selective ATP/GTP-competitive protein kinase inhibitor. It has been shown to specifically inhibit casein kinase IIα (CK2α) and dual-specificity tyrosine-(Y)-phosphorylation regulated kin |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
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IUPAC Name | 4,5,6,7-tetrabromo-2H-benzotriazole |
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INCHI | InChI=1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13) |
InChi Key | OMZYUVOATZSGJY-UHFFFAOYSA-N |
Canonical SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br |
Isomeric SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br |
WGK Germany | 3 |
Alternate CAS | 17374-26-4 |
PubChem CID | 1694 |
NSC Number | 231634 |
MeSH Entry Terms | 4,5,6,7-tetrabromobenzotriazole;TBB benzotriazole |
Molecular Weight | 434.71 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2313238 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313239 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313240 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313241 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313242 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313243 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313244 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313245 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313713 | Certificate of Analysis | Aug 25, 2023 | T125016 |
I2313738 | Certificate of Analysis | Aug 25, 2023 | T125016 |
F1502073 | Certificate of Analysis | Jan 16, 2023 | T125016 |
Solubility | Soluble in DMSO (100 mM), ethanol (20 mM), DMF (~20 mg/ml), and 1:1 solution of DMF:PBS (pH7.2, ~0.5 mg/ml). |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 264 °C |
WGK Germany | 3 |
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Starting at $241.90
1. Rui Hou, Qianyi Huang, Yunfeng Pan, Lang Lin, Shan Liu, Hengxiang Li, Xiangrong Xu. (2022) Novel Brominated Flame Retardants (NBFRs) in a Tropical Marine Food Web from the South China Sea: The Influence of Hydrophobicity and Biotransformation on Structure-Related Trophodynamics. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56 (5): (3147–3158). [PMID:35175039] |
1. Sarno S, de Moliner E, Ruzzene M, Pagano MA, Battistutta R, Bain J, Fabbro D, Schoepfer J, Elliott M, Furet P et al.. (2003) Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).. Biochem J, 374 (Pt 3): (639-46). [PMID:12816539] |
2. González N et al.. (2016) Ck2-Dependent Phosphorylation Is Required to Maintain Pax7 Protein Levels in Proliferating Muscle Progenitors.. PLoS One, 11 (5): (e0154919). [PMID:27144531] |
3. Sano K et al.. (2021) Tyrosine 136 phosphorylation of a-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.. Acta Neuropathol Commun, 9 (182). [PMID:34772466] |
4. Rui Hou, Qianyi Huang, Yunfeng Pan, Lang Lin, Shan Liu, Hengxiang Li, Xiangrong Xu. (2022) Novel Brominated Flame Retardants (NBFRs) in a Tropical Marine Food Web from the South China Sea: The Influence of Hydrophobicity and Biotransformation on Structure-Related Trophodynamics. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56 (5): (3147–3158). [PMID:35175039] |