17374-26-4|4,5,6,7-tetrabromobenzotriazole|TBB|4,5,6,7-Tetrabromo-1H-benzotriazole|TBBt|4,5,6,7-tetrabromo-2H-benzotriazole|4,5,6,7-Tetrabromo-1H-benzo[d][1,2,3]triazole|Casein Kinase II Inhibitor I|TETRABROMO-2-BENZOTRIAZOLE|NSC 231634|CHEMBL177820|NSC23
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
TBB is a cell-permeable benzotriazolo compound that acts as a highly selective ATP/GTP-competitive protein kinase inhibitor. It has been shown to specifically inhibit casein kinase IIα (CK2α) and dual-specificity tyrosine-(Y)-phosphorylation regulated kin
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). A highly selective CK2α, Dyrk1A, and NS3 viral helicase inhibitor.
Associated Targets
CNKSR3Tbio Connector enhancer of kinase suppressor of ras 3 0 Activities
1.Sarno S, de Moliner E, Ruzzene M, Pagano MA, Battistutta R, Bain J, Fabbro D, Schoepfer J, Elliott M, Furet P et al.. (2003) Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).. Biochem J, 374 (Pt 3):(639-46). [PMID:12816539]
2.González N et al.. (2016) Ck2-Dependent Phosphorylation Is Required to Maintain Pax7 Protein Levels in Proliferating Muscle Progenitors.. PLoS One, 11 (5):(e0154919). [PMID:27144531]
3.Sano K et al.. (2021) Tyrosine 136 phosphorylation of a-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.. Acta Neuropathol Commun, 9 (182). [PMID:34772466]
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I2313238