TC-N 22A - ≥98%(HPLC), high purity , CAS No.1314140-00-5, Allosteric modulator of mGlu 4 receptor

Item Number

T288621

• Synonyms: (Z)-N-(5,6-dihydropyrazolo[3',4':6,7]cyclohepta[1,2-d]thiazol-2(1H,4H,8H)-ylidene)pyridin-2-amine；4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Potent and selective mGlu4receptor positive allosteric modulator (EC50= 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4over mGlu1, mGlu2, mGlu3, mGlu5and mGlu7receptors (EC50values are > 10μM). Brain penetrant.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of mGlu 4 receptor

Product Description

Product description

TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo