| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T288621-5mg | 5mg | 3 | $135.90 | |
| T288621-10mg | 10mg | 2 | $209.90 | |
| T288621-25mg | 25mg | 1 | $470.90 | |
| T288621-50mg | 50mg | 1 | $877.90 | |
| T288621-100mg | 100mg | 1 | $1,580.90 |
Potent and selective positive allosteric modulator of mGlu4receptors
| Specifications & Purity | Moligand™, ≥98%(HPLC) |
|---|---|
| Biochemical and Physiological Mechanisms | Potent and selective mGlu4receptor positive allosteric modulator (EC50= 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4over mGlu1, mGlu2, mGlu3, mGlu5and mGlu7receptors (EC50values are > 10μM). Brain penetrant. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | ALLOSTERIC MODULATOR |
| Mechanism of action | Allosteric modulator of mGlu 4 receptor |
| Product Description | Product description TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 488201370 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488201370 |
| IUPAC Name | N-pyridin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amine |
| INCHI | InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18) |
| InChi Key | DBISXWCOHGUFSF-UHFFFAOYSA-N |
| Canonical SMILES | C1CC2=C(C=NN2)C3=C(C1)SC(=N3)NC4=CC=CC=N4 |
| Isomeric SMILES | C1CC2=C(C=NN2)C3=C(C1)SC(=N3)NC4=CC=CC=N4 |
| PubChem CID | 46836562 |
| Molecular Weight | 283.35 |
Find and download the COA for your product by matching the lot number on the packaging.
10 results found
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2320202 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320206 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320208 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320227 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320236 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320237 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320240 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320242 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320254 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| E2320257 | Certificate of Analysis | Apr 10, 2023 | T288621 |
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 14.17, Max Conc. mM: 50 |
|---|---|
| Molecular Weight | 283.350 g/mol |
| XLogP3 | 2.800 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 283.089 Da |
| Monoisotopic Mass | 283.089 Da |
| Topological Polar Surface Area | 94.700 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 342.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
