Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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T287320-1mg | 1mg | In stock | $83.90 | |
T287320-5mg | 5mg | In stock | $345.90 | |
T287320-10mg | 10mg | In stock | $553.90 | |
T287320-25mg | 25mg | In stock | $1,107.90 | |
T287320-50mg | 50mg | In stock | $1,771.90 | |
T287320-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,830.90 |
Potent and highly selective ROCK inhibitor; orally active
Synonyms | ROCK Inhibitor | 867017-68-3 | TC-S 7001 | Azaindole 1 | Azaindole-1 | ROCK-IN-2 | 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine | 6-chloro-4-N-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl] |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent and highly selective ROCK inhibitor (IC50values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively). Exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent e |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | 6-chloro-4-N-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]pyrimidine-2,4-diamine |
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INCHI | InChI=1S/C18H13ClF2N6O/c1-8-7-24-17-15(8)12(2-3-23-17)28-16-10(20)4-9(5-11(16)21)25-14-6-13(19)26-18(22)27-14/h2-7H,1H3,(H,23,24)(H3,22,25,26,27) |
InChi Key | NRSGWEVTVGZDFC-UHFFFAOYSA-N |
Canonical SMILES | CC1=CNC2=NC=CC(=C12)OC3=C(C=C(C=C3F)NC4=CC(=NC(=N4)N)Cl)F |
Isomeric SMILES | CC1=CNC2=NC=CC(=C12)OC3=C(C=C(C=C3F)NC4=CC(=NC(=N4)N)Cl)F |
PubChem CID | 11524200 |
Molecular Weight | 402.79 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
A2304123 | Certificate of Analysis | Aug 11, 2022 | T287320 |
K2225721 | Certificate of Analysis | Aug 11, 2022 | T287320 |
K2225722 | Certificate of Analysis | Aug 11, 2022 | T287320 |
K2225773 | Certificate of Analysis | Aug 11, 2022 | T287320 |
K2225774 | Certificate of Analysis | Aug 11, 2022 | T287320 |
K2225775 | Certificate of Analysis | Aug 11, 2022 | T287320 |
K2225776 | Certificate of Analysis | Aug 11, 2022 | T287320 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 40.28, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 40.28, Max Conc. mM: 100 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |