TCID - 97%, high purity , CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3

Item Number
T169439
Grouped product items
SKUSizeAvailabilityPrice Qty
T169439-1mg
1mg
In stock
$28.90
T169439-5mg
5mg
In stock
$63.90
T169439-25mg
25mg
In stock
$233.90
T169439-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$842.90

Potent and selective ubiquitin C-terminal hydrolase-L3 inhibitor

Basic Description

Synonyms30675-13-9 | TCID | 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione | 4,5,6,7-Tetrachloroindan-1,3-dione | UCH-L3 Inhibitor | 4,5,6,7-tetrachloroindene-1,3-dione | 4,5,6,7-Tetrachloroindane-1,3-dione | 1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro- | CHEMBL1241028 | compound 6
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsTCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of ubiquitin C-terminal hydrolase L3
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (50 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4,5,6,7-tetrachloroindene-1,3-dione
INCHI InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
InChi Key IDLAOWFFKWRNHB-UHFFFAOYSA-N
Canonical SMILES C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
Isomeric SMILES C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
PubChem CID 2729042
Molecular Weight 283.92

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
J2106095Certificate of AnalysisJul 08, 2024 T169439
J2106096Certificate of AnalysisJul 08, 2024 T169439
J2106097Certificate of AnalysisJul 08, 2024 T169439
J2106098Certificate of AnalysisJul 08, 2024 T169439

Chemical and Physical Properties

SolubilityDMSO: 5 mg/mL, clear

Related Documents

Citations of This Product

1. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo.  (2023)  Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents.  Pharmaceuticals,  16  (5): (639).  [PMID:37242423]

References

1. Love KR, Catic A, Schlieker C, Ploegh HL.  (2007)  Mechanisms, biology and inhibitors of deubiquitinating enzymes..  Nat Chem Biol,  (11): (697-705).  [PMID:17948018]
2. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo.  (2023)  Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents.  Pharmaceuticals,  16  (5): (639).  [PMID:37242423]

Solution Calculators