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TCID - 97%, high purity , CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3

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TCID - 97%, high purity , CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3

2 Citations

Moligand™

≥97%

CAS#: 30675-13-9
Formula: C₉H₂Cl₄O₂
Molecular Weight: 283.92
PubChem CID: 2729042

Item Number

T169439

Grouped product items
SKU	Size	Availability	Price
T169439-1mg	1mg	In stock	$28.90
T169439-5mg	5mg	In stock	$63.90
T169439-25mg	25mg	In stock	$233.90
T169439-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$842.90

Potent and selective ubiquitin C-terminal hydrolase-L3 inhibitor

View related series

ubiquitin C-terminal hydrolase L3 Inhibitor

Basic Description

Synonyms	4,5,6,7-Tetrachloroindane-1,3-dione \| C9H2Cl4O2 \| Maybridge1_006552 \| GTPL8660 \| HMS3653C11 \| HMS560B18 \| UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4,5,6,7-tetrachloroindan-1,3-dione \| UCH-L3 \| UCH-L3 Inhibitor \| 4,5,6,7-Tetrachloro indane-1,3-dione \| HY-18638
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	TCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ubiquitin C-terminal hydrolase L3
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (2 Activities)

Discover Target: UCHL3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (50 Activities)

Discover Target: UCHL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4,5,6,7-tetrachloroindene-1,3-dione
INCHI	InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
InChi Key	IDLAOWFFKWRNHB-UHFFFAOYSA-N
Canonical SMILES	C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
Isomeric SMILES	C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
PubChem CID	2729042
Molecular Weight	283.92

Database links

ChEMBL Ligand	CHEMBL1241028
PubChem CID	2729042
CAS Registry No.	30675-13-9

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
J2106095	Certificate of Analysis	Jul 08, 2024	T169439
J2106096	Certificate of Analysis	Jul 08, 2024	T169439
J2106097	Certificate of Analysis	Jul 08, 2024	T169439
J2106098	Certificate of Analysis	Jul 08, 2024	T169439

Chemical and Physical Properties

Solubility	DMSO: 5 mg/mL, clear

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo. (2023) Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents. Pharmaceuticals, 16 (5): (639). [PMID:37242423]
2. Wang Qian, He Yuan, Lu Rui, Wang Wen-Ming, Yang Ke-Wu, Fan Hai Ming, Jin Yi, Blackburn G. Michael. (2018) Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids. BIOSCIENCE REPORTS, 38 (2): [PMID:29507059]

References

1. Love KR, Catic A, Schlieker C, Ploegh HL. (2007) Mechanisms, biology and inhibitors of deubiquitinating enzymes.. Nat Chem Biol, 3 (11): (697-705). [PMID:17948018]
2. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo. (2023) Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents. Pharmaceuticals, 16 (5): (639). [PMID:37242423]
3. Wang Qian, He Yuan, Lu Rui, Wang Wen-Ming, Yang Ke-Wu, Fan Hai Ming, Jin Yi, Blackburn G. Michael. (2018) Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids. BIOSCIENCE REPORTS, 38 (2): [PMID:29507059]

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