TCN 213 - 98%, high purity , CAS No.556803-08-8, Allosteric modulator of GluN2A

Item Number

T286921

Grouped product items
SKU	Size	Availability	Price
T286921-5mg	5mg	In stock	$117.90
T286921-10mg	10mg	In stock	$187.90
T286921-25mg	25mg	In stock	$375.90
T286921-50mg	50mg	In stock	$612.90
T286921-100mg	100mg	In stock	$969.90
T286921-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,182.90

NMDA antagonist; selective for GluN2A over GluN2B containing receptors

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Basic Description

Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	NMDA receptor antagonists are selective for receptor-containing GluN1/GluN2B (formally NR1/NR2B), and selective for GluN1/GluN2A (formally NR1/NR2A) (pIC50 = 5.4).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of GluN2A

Names and Identifiers

IUPAC Name	2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclohexylmethyl)acetamide
INCHI	InChI=1S/C18H24N4OS2/c23-16(19-11-14-7-3-1-4-8-14)13-24-18-22-21-17(25-18)20-12-15-9-5-2-6-10-15/h2,5-6,9-10,14H,1,3-4,7-8,11-13H2,(H,19,23)(H,20,21)
InChi Key	XBAZPYFIYYCZBO-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)CNC(=O)CSC2=NN=C(S2)NCC3=CC=CC=C3
Isomeric SMILES	C1CCC(CC1)CNC(=O)CSC2=NN=C(S2)NCC3=CC=CC=C3
PubChem CID	2608149
MeSH Entry Terms	N-(cyclohexylmethyl)-2-((5-((phenylmethyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide;TCN 213
Molecular Weight	376.54

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
L2417141	Certificate of Analysis	Dec 27, 2024	T286921
L2116035	Certificate of Analysis	Sep 20, 2024	T286921
L2116036	Certificate of Analysis	Sep 20, 2024	T286921
L2116037	Certificate of Analysis	Sep 20, 2024	T286921
L2116038	Certificate of Analysis	Sep 20, 2024	T286921
L2116039	Certificate of Analysis	Sep 20, 2024	T286921
L2116040	Certificate of Analysis	Sep 20, 2024	T286921

References

1. McKay S, Griffiths NH, Butters PA, Thubron EB, Hardingham GE, Wyllie DJ. (2012) Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.. Br J Pharmacol, 166 (3): (924-37). [PMID:22022974] [10.1021/op500134e]

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Basic Description