Potent, dual orexin receptor antagonist (Kivalues are 0.2 and 3 nM for OX2and OX1receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administrationin vivoand blocksorexin-A mediated increases in feeding behaviour. Brain penet
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of OX 1 receptor;Antagonist of OX 2 receptor
Product Description
Product Describtion: TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). IC50 value: 0.2 nM (Ki, OX2 receptor); 3 nM (Ki, OX1 receptor) ；Target: OX2 and OX1 receptor TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock.Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze.
A2205625