TCS 1105 - ≥99%(HPLC), high purity , CAS No.185391-33-7

Item Number

T286790

Grouped product items
SKU	Size	Availability	Price
T286790-5mg	5mg	In stock	$83.90
T286790-10mg	10mg	In stock	$129.90
T286790-25mg	25mg	In stock	$290.90
T286790-50mg	50mg	In stock	$551.90
T286790-100mg	100mg	In stock	$991.90
T286790-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,231.90

GABAAα2 benzodiazepine agonist

Basic Description

Synonyms	185391-33-7 \| TCS 1105 \| N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide \| N-[(4-fluorophenyl)methyl]-2-(1H-indol-3-yl)-2-oxoacetamide \| TCS1105 \| N-[(-4-Fluorophenyl)methyl]-alpha-oxo-1H-indole-3-acetamide \| CHEMBL127135 \| SCHEMBL22026691 \| DTXSID60878106 \| BDBM500552
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	GABAAbenzodiazepine receptor (BZR) ligand. Acts as an agonist atα2and antagonist atα1benzodiazepine receptors (Kivalues are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(non-human)

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gabrp GABA-A receptor; anion channel (5731 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gabrg2 GABA A receptor alpha-5/beta-3/gamma-2 (149 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[(4-fluorophenyl)methyl]-2-(1H-indol-3-yl)-2-oxoacetamide
INCHI	InChI=1S/C17H13FN2O2/c18-12-7-5-11(6-8-12)9-20-17(22)16(21)14-10-19-15-4-2-1-3-13(14)15/h1-8,10,19H,9H2,(H,20,22)
InChi Key	VWCCHJFFYCGXFL-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=CN2)C(=O)C(=O)NCC3=CC=C(C=C3)F
Isomeric SMILES	C1=CC=C2C(=C1)C(=CN2)C(=O)C(=O)NCC3=CC=C(C=C3)F
PubChem CID	2986030
Molecular Weight	296.3

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
I2219280	Certificate of Analysis	Jul 01, 2022	T286790
I2219281	Certificate of Analysis	Jul 01, 2022	T286790
I2219282	Certificate of Analysis	Jul 01, 2022	T286790
I2219354	Certificate of Analysis	Jul 01, 2022	T286790
I2219355	Certificate of Analysis	Jul 01, 2022	T286790

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Basic Description