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TCS 359 - ≥99%, high purity , CAS No.301305-73-7, Inhibitor of fms related receptor tyrosine kinase 3
Potent FLT3 receptor tyrosine kinase inhibitor
Basic Description Synonyms 301305-73-7|TCS 359|Flt-3 inhibitor|2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide|TCS-359|2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide|2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-te Specifications & Purity ≥99% Storage Temp Store at -20°C,Argon charged Shipped In Dry ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of fms related receptor tyrosine kinase 3 Product Description TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC50 of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC50 of 340 nM.
A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor
Names and Identifiers IUPAC Name 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide INCHI InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22) InChi Key FSPQCTGGIANIJZ-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC Isomeric SMILES COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC WGK Germany 3 PubChem CID 1048845 Molecular Weight 360.43
Chemical and Physical Properties Solubility DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Sensitivity Light sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
References 1. Patch RJ, Baumann CA, Liu J, Gibbs AC, Ott H, Lattanze J, Player MR. (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.. Bioorg Med Chem Lett, 16 (12): (3282-6). [PMID:16580199 ]
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