TCS 46b - ≥98%(HPLC), high purity , CAS No.302799-86-6

Item Number

T286863

Grouped product items
SKU	Size	Availability	Price
T286863-5mg	5mg	In stock	$131.90
T286863-10mg	10mg	In stock	$211.90
T286863-25mg	25mg	In stock	$444.90
T286863-50mg	50mg	In stock	$711.90
T286863-100mg	100mg	In stock	$1,206.90

GluN1A/GluN2B-selective NMDA antagonist

Basic Description

Synonyms	TCS 46B\|302799-86-6\|5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one\|CHEMBL117260\|1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one\|SCHEMBL12619204\|DTXSID30432052\|BDBM50091637\|AKOS024457292\|NCGC00378727-01\|HY-107707\|CS-0029
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Orally active, subtype-selective GluN1A/GluN2B (formally NR1A/NR2B) NMDA receptor antagonist (IC50values are 5.3, 35000 and > 100000 nM for GluN1A/2B (NR1A/2B), GluN1A/2B (NR1A/2B) and GluN1A/2C (NR1A/2C) receptor subtypes respectively). Potentiates the e
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one
INCHI	InChI=1S/C22H23N3O/c26-22-23-20-9-8-18(16-21(20)24-22)7-4-12-25-13-10-19(11-14-25)15-17-5-2-1-3-6-17/h1-3,5-6,8-9,16,19H,10-15H2,(H2,23,24,26)
InChi Key	JJEXWPHPFZLTCU-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4
Isomeric SMILES	C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4
PubChem CID	9863010
Molecular Weight	345.44

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
G2227158	Certificate of Analysis	Jun 10, 2022	T286863
G2227159	Certificate of Analysis	Jun 10, 2022	T286863
G2227160	Certificate of Analysis	Jun 10, 2022	T286863
G2227161	Certificate of Analysis	Jun 10, 2022	T286863
G2227162	Certificate of Analysis	Jun 10, 2022	T286863

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Basic Description