Basic Description

Synonyms	HY-107707 \| AKOS024457292 \| 5-(3-(4-benzylpiperidin-1-yl)prop-1-ynyl)-1H-benzo[d]imidazol-2(3H)-one \| BDBM50091637 \| J-017852 \| TCS 46B \| NCGC00378727-01 \| 5-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1,3-dihydro-benzoimidazol-2-one \| DTXSID30432052 \| SCHE
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Orally active, subtype-selective GluN1A/GluN2B (formally NR1A/NR2B) NMDA receptor antagonist (IC50values are 5.3, 35000 and > 100000 nM for GluN1A/2B (NR1A/2B), GluN1A/2B (NR1A/2B) and GluN1A/2C (NR1A/2C) receptor subtypes respectively). Potentiates the e
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (1 Activities)

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin Dopamine D2 receptor (23596 Activities)

Discover Target: DRD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)

Discover Target: GRIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIN1 Tclin Glutamate NMDA receptor; GRIN1/GRIN2B (726 Activities)

Discover Target: GRIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one
INCHI	InChI=1S/C22H23N3O/c26-22-23-20-9-8-18(16-21(20)24-22)7-4-12-25-13-10-19(11-14-25)15-17-5-2-1-3-6-17/h1-3,5-6,8-9,16,19H,10-15H2,(H2,23,24,26)
InChi Key	JJEXWPHPFZLTCU-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4
Isomeric SMILES	C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4
PubChem CID	9863010
Molecular Weight	345.44

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
G2227158	Certificate of Analysis	Jun 10, 2022	T286863
G2227159	Certificate of Analysis	Jun 10, 2022	T286863
G2227160	Certificate of Analysis	Jun 10, 2022	T286863
G2227161	Certificate of Analysis	Jun 10, 2022	T286863
G2227162	Certificate of Analysis	Jun 10, 2022	T286863

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 34.54, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 34.54, Max Conc. mM: 100

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SKU	Size	Availability	Price
T286863-5mg	5mg	In stock	$131.90
T286863-10mg	10mg	In stock	$211.90
T286863-25mg	25mg	In stock	$444.90
T286863-50mg	50mg	In stock	$711.90
T286863-100mg	100mg	In stock	$1,206.90

TCS 46b - ≥98%(HPLC), high purity , CAS No.302799-86-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

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