TCS JNK 6o - 10mM in DMSO, high purity , CAS No.894804-07-0

Item Number

T426722

• Synonyms: JNK Inhibitor VIII | 894804-07-0 | TCS JNK 6o | N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide | aminopyridine deriv. 2 | TCS JNK 6o(JNK Inhibitor VIII) | N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide | Kinome_3020 | JN
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: Cell permeable: yes Target Ki: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively Product competes with ATP. Reversible: yes
• Storage Temp: Protected from light,Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Product Description
A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.