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TCS PIM-1 1 - ≥98%(HPLC), high purity , CAS No.491871-58-0
Selective, ATP-competitive Pim-1 kinase inhibitor
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively). Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile INCHI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23) InChi Key SVSYJTYGPLVUOZ-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)C2=C(C(=O)NC(=C2)C3=C(C=CC(=C3)Br)O)C#N Isomeric SMILES C1=CC=C(C=C1)C2=C(C(=O)NC(=C2)C3=C(C=CC(=C3)Br)O)C#N PubChem CID 1235170 Molecular Weight 367.2
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 36.72, Max Conc. mM: 100
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C2304078