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TDI-11861 , CAS No.T614359, Inhibitor of adenylyl cyclase 10

Item Number
T614359
Grouped product items
SKUSizeAvailabilityPrice Qty
T614359-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
T614359-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,613.90
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adenylyl cyclase 10 Inhibitor

Basic Description

Synonymscompound 33;TDI11861
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of adenylyl cyclase 10

Associated Targets(Human)

ADCY10 Tchem Adenylate cyclase type 10 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADCY9 Tbio Adenylate cyclase type IX (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADCY8 Tchem Adenylate cyclase type VIII (190 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADCY1 Tchem Brain adenylate cyclase 1 (372 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADCY10 Tchem Adenylate cyclase type 10 (96 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Adcy5 Adenylate cyclase type V (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adcy2 Adenylate cyclase type II (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name [(3R)-4-[2-[2-[[3-(2-amino-6-chloropyrimidin-4-yl)-1-(difluoromethyl)pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol
INCHI InChI=1S/C22H25ClF2N6O3/c23-19-10-17(27-22(26)28-19)20-15(11-31(29-20)21(24)25)9-14-3-1-2-4-18(14)34-8-6-30-5-7-33-13-16(30)12-32/h1-4,10-11,16,21,32H,5-9,12-13H2,(H2,26,27,28)/t16-/m1/s1
InChi Key XVGSKZXXLKUEIO-MRXNPFEDSA-N
Canonical SMILES Nc1nc(Cl)cc(c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCOC[C@H]2CO)n1
Isomeric SMILES C1COC[C@H](N1CCOC2=CC=CC=C2CC3=CN(N=C3C4=CC(=NC(=N4)N)Cl)C(F)F)CO
PubChem CID 166101565

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S et al..  (2022)  Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates..  J Med Chem,  65  (22): (15208-15226).  [PMID:36346696]
2. Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT et al..  (2023)  On-demand male contraception via acute inhibition of soluble adenylyl cyclase..  Nat Commun,  14  (1): (637).  [PMID:36788210]

Solution Calculators

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