Tebipenem Pivoxil - ≥98%, high purity , Bacterial penicillin-binding protein inhibitor, CAS No.161715-24-8, Bacterial penicillin-binding protein inhibitor

Item Number
T129675
Grouped product items
SKUSizeAvailabilityPrice Qty
T129675-5mg
5mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$9.90
T129675-25mg
25mg
In stock
$13.90
T129675-100mg
100mg
In stock
$27.90
T129675-250mg
250mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$61.90
T129675-1g
1g
In stock
$221.90

Basic Description

SynonymsTebipenem pivoxil | 161715-24-8 | Orapenem | TBPM-PI | ME1211 | L-084 | LJC 11,084 | 2,2-dimethylpropanoyloxymethyl (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | L
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionBacterial penicillin-binding protein inhibitor
Note5mg、25mg卖完停产,不再备货
Product Description

Tebipenem pivoxil is an oral carbapenem antibiotic, use to treat otolaryngologic and respiratory infections

Product Properties

ALogP2.3

Associated Targets(Human)

Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rhesus monkey (3147 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LLC-PK1 (2135 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488196404
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488196404
IUPAC Name 2,2-dimethylpropanoyloxymethyl (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
INCHI InChI=1S/C22H31N3O6S2/c1-11-15-14(12(2)26)18(27)25(15)16(19(28)30-10-31-20(29)22(3,4)5)17(11)33-13-8-24(9-13)21-23-6-7-32-21/h11-15,26H,6-10H2,1-5H3/t11-,12-,14-,15-/m1/s1
InChi Key SNUDIPVBUUXCDG-QHSBEEBCSA-N
Canonical SMILES CC1C2C(C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)C(C)O
Isomeric SMILES C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)[C@@H](C)O
PubChem CID 9892071
Molecular Weight 497.63

Certificates

Certificate of Analysis(COA)

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9 results found

Lot NumberCertificate TypeDateItem
C1722084Certificate of AnalysisJun 12, 2024 T129675
D23201123Certificate of AnalysisMar 15, 2023 T129675
D23201137Certificate of AnalysisMar 15, 2023 T129675
D2321243Certificate of AnalysisMar 15, 2023 T129675
D2321249Certificate of AnalysisMar 15, 2023 T129675
D2321250Certificate of AnalysisMar 15, 2023 T129675
D2321251Certificate of AnalysisMar 15, 2023 T129675
D2321252Certificate of AnalysisMar 15, 2023 T129675
D2321255Certificate of AnalysisMar 15, 2023 T129675

Chemical and Physical Properties

SolubilityDMSO 99 mg/mL Water <1 mg/mL Ethanol 99 mg/mL

Related Documents

References

1. Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H, Shibasaki S, Kurosawa T, Tamai I.  (2010)  Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport..  Mol Pharm,  (5): (1747-56).  [PMID:20735088]
2. Fujimoto K, Takemoto K, Hatano K, Nakai T, Terashita S, Matsumoto M, Eriguchi Y, Eguchi K, Shimizudani T, Sato K et al..  (2013)  Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals..  Antimicrob Agents Chemother,  57  (2): (697-707).  [PMID:23147735]
3. Hazra S, Xu H, Blanchard JS.  (2014)  Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis..  Biochemistry,  53  (22): (3671-8).  [PMID:24846409]

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