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Tegoprazan - 98%, high purity , CAS No.942195-55-3, Inhibitor of ATP4A

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Tegoprazan - 98%, high purity , CAS No.942195-55-3, Inhibitor of ATP4A

Moligand™

≥98%

CAS#: 942195-55-3
Formula: C₂₀H₁₉F₂N₃O₃
Molecular Weight: 387.38
PubChem CID: 23582846

Item Number

T420066

Grouped product items
SKU	Size	Availability	Price
T420066-5mg	5mg	In stock	$216.90
T420066-25mg	25mg	In stock	$672.90
T420066-50mg	50mg	In stock	$1,088.90
T420066-100mg	100mg	In stock	$1,731.90

View related series

ATP4A Inhibitor

Basic Description

Synonyms	HY-17623 \| 7-[[(4S)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide \| E83739 \| GTPL12008 \| Emixustat HCl \| AS-84160 \| EX-A4304 \| Tegoprazan \| doi:10.14272/QCZZSANNLWPGEA-UHFFFAOYSA-N.1 \| LXI-15028 \| TEGOPR
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ATP4A
Product Description	Biological activity Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028, RQ-00000004) is a novel potent and highly selective inhibitor of gastric H+/K+-ATPase with IC50s ranging from 0.29 μM to 0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro, respectively.

Product Properties

ALogP	3.2

Associated Targets(Human)

ATP4A Tclin Potassium-transporting ATPase alpha chain 1 (0 Activities)

Discover Target: ATP4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl]oxy]-N,N,2-trimethyl-3H-benzimidazole-5-carboxamide
INCHI	InChI=1S/C20H19F2N3O3/c1-10-23-14-6-11(20(26)25(2)3)7-17(19(14)24-10)28-15-4-5-27-16-9-12(21)8-13(22)18(15)16/h6-9,15H,4-5H2,1-3H3,(H,23,24)/t15-/m0/s1
InChi Key	CLIQCDHNPDMGSL-HNNXBMFYSA-N
Canonical SMILES	CC1=NC2=C(N1)C=C(C=C2OC3CCOC4=C3C(=CC(=C4)F)F)C(=O)N(C)C
Isomeric SMILES	CC1=NC2=C(N1)C=C(C=C2O[C@H]3CCOC4=C3C(=CC(=C4)F)F)C(=O)N(C)C
PubChem CID	23582846
Molecular Weight	387.38

Database links

PubChem CID	23582846
CAS Registry No.	942195-55-3
ChEMBL Ligand	CHEMBL4297583
RCSB PDB Ligand	8BN

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
J2214382	Certificate of Analysis	Jun 07, 2022	T420066
J2214383	Certificate of Analysis	Jun 07, 2022	T420066
J2214429	Certificate of Analysis	Jun 07, 2022	T420066
J2214430	Certificate of Analysis	Jun 07, 2022	T420066

Chemical and Physical Properties

Solubility	Solubility (25°C): 77 mg/mL(198.77 mM)in DMSO；Insoluble in water； 77 mg/mL in Ethanol

References

1. Takahashi N, Take Y. (2018) Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility.. J Pharmacol Exp Ther, 364 (2): (275-286). [PMID:29180359] [10.1021/op500134e]

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